TPM4

Gene Symbol	TPM4
Entrez Gene	7171
Alt Symbol	HEL-S-108
Species	Human
Gene Type	protein-coding
Description	tropomyosin 4
Other Description	TM30p1|epididymis secretory protein Li 108|tropomyosin alpha-4 chain|tropomyosin-4
Swissprots	P67936 Q15659 Q9UCS4 Q9UCS1 Q9H8Q3 Q9UCS3 Q5U0D9 Q9UCS2 P07226 Q9BU85
Accessions	EAW84521 EAW84522 EAW84523 EAW84524 P67936 AF186109 AAG17014 AK023385 BAB14554 AK095546 AK096732 AK300136 BAG61923 AK301285 BAG62844 AK307538 AK315076 BAG37545 BC002827 AAH02827 BC037576 AAH37576 BC067225 AAH67225 BT019634 AAV38440 DA032511 DC365500 FJ224305 ACI45997 M12127 AAA36774 X05276 CAA28888 XM_005260042 XP_005260099 XM_006722865 XP_006722928 XM_011528231 XP_011526533 XM_011528232 XP_011526534 NM_001145160 NP_001138632 NM_003290 NP_003281
Function	Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. {ECO:0000269|PubMed:1836432}.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269|PubMed:1836432}.
Top Pathways	Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TPM4 full length protein - ab105576 from Abcam Category Protein Source E. coli Species Human

TPM4 Antibody Blocking Peptide - LS-E1918 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

tropomyosin-4 Recombinant Protein - H00007171-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human tropomyosin-4 Protein - NBP1-51062 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E. coli Species Human

TPM4-Antibody-N-term-Blocking-Peptide - BP19539a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TPM4-Antibody-N-term-Blocking-peptide - BP12756a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TM30p1 protein - orb139796 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

Human TPM4 protein - orb169467 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

TPM4 protein (His tag) - 80R-1750 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

Tropomyosin-4 (TPM4) (1-248, His-tag) - AR09932PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

Tropomyosin-4 (TPM4) (1-248, His-tag) - AR09932PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

Tropomyosin-4 (TPM4) - H00007171-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Tropomyosin-4 (TPM4) - H00007171-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Tropomyosin-4, Human Recombinant - 228-12941-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Tropomyosin-4 - 228-12941-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Tropomyosin-4 - 228-12941-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

TPM4, 1-248aa, Human, His tag, E.coli - 01-1919-4 from ARP American Research Products Category Protein Prices $149.00, $369.00, $849.00 Sizes 10 µg, 50 µg, 250 µg Species Human

TPM4 fusion protein - Ag4679 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TPM4 fusion protein - ag6947 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TPM4 Human - PRPS-194 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human TPM4 Protein - BP002015-PRO-187 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

TPM4, 1-248aa, Recombinant Protein - GWB-P1046F from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 50 μg, 250 μg Source E.coli Species Human

TPM4 Human Protein - GWB-BSP697 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human Tropomyosin 4, His-tagged - TPM4-3003H from Creative Biomart Category Protein

Recombinant Human TPM4, His-tagged - TPM4-30818TH from Creative Biomart Category Protein Source E. coli

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