NCSTN

Gene Symbol	NCSTN
Entrez Gene	23385
Alt Symbol	ATAG1874
Species	Human
Gene Type	protein-coding
Description	nicastrin
Other Description	anterior pharynx-defective 2
Swissprots	Q92542 Q86VV5 Q5T207 Q5T208
Accessions	EAW52720 EAW52721 EAW52722 Q92542 AF240468 AAG11412 AK296153 BAG58892 AK299142 BAG61194 AK310741 AK314764 BAG37302 AY359120 AAQ89478 BC047621 AAH47621 BC100024 CN429672 D87442 BAA13383 JF432369 ADZ15586 XM_005245053 XP_005245110 XM_011509363 XP_011507665 XM_011509364 XP_011507666 NM_001290184 NP_001277113 NM_001290186 NP_001277115 NM_015331 NP_056146
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11396676}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

nicastrin, ELISA Kit - MBS9334840 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

Nicastrin (NCSTN), ELISA Kit - MBS9311810 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Custom Human Nicastrin ELISA - ELH-NCSTN-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human Nicastrin ELISA Kit - orb384675 from Biorbyt Category ELISA Kit

Human NCSTN ELISA Kit - E026510 from Biobool Category ELISA Kit Sensitivity 0.1ng/ml.

Nicastrin (NCSTN), ELISA Kit - MBS9358081 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nicastrin (NCSTN), ELISA Kit - MBS9360657 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nicastrin (NCSTN), ELISA Kit - MBS9367306 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nicastrin (NCSTN), ELISA Kit - MBS9355970 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nicastrin (NCSTN), ELISA Kit - MBS9359436 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nicastrin (NCSTN), ELISA Kit - MBS9360479 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Nicastrin (NCSTN), ELISA Kit - MBS9380435 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more