NCSTN

Gene Symbol	NCSTN
Entrez Gene	23385
Alt Symbol	ATAG1874
Species	Human
Gene Type	protein-coding
Description	nicastrin
Other Description	anterior pharynx-defective 2
Swissprots	Q92542 Q86VV5 Q5T207 Q5T208
Accessions	EAW52720 EAW52721 EAW52722 Q92542 AF240468 AAG11412 AK296153 BAG58892 AK299142 BAG61194 AK310741 AK314764 BAG37302 AY359120 AAQ89478 BC047621 AAH47621 BC100024 CN429672 D87442 BAA13383 JF432369 ADZ15586 XM_005245053 XP_005245110 XM_011509363 XP_011507665 XM_011509364 XP_011507666 NM_001290184 NP_001277113 NM_001290186 NP_001277115 NM_015331 NP_056146
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11396676}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nicastrin peptide - ab51490 from Abcam Category Peptide Species Human

Human Nicastrin protein fragment - ab153224 from Abcam Category Protein Source Wheat germ Species Human

Nicastrin peptide - ab4977 from Abcam Category Peptide

NCSTN / Nicastrin Antibody Blocking Peptide - LS-E30288 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NCSTN / Nicastrin Antibody Blocking Peptide - LS-E30289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Nicastrin Protein - H00023385-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Nicastrin Recombinant Protein - H00023385-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

Nicastrin Blocking Peptide - NBP1-77270PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Nicastrin Blocking Peptide - NBP1-77269PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Nicastrin Peptide - P1927 from Novus Biologicals Category Peptide Species Human

Nicastrin-NICA-Antibody-N-term-Blocking-peptide - BP6303a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human NCSTN His tag protein - orb83526 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human Nicastrin Protein - abx068289 from Abbexa Category Protein Source E.coli Species Human

Nicastrin - H00023385-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Nicastrin - H00023385-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Nicastrin Control Peptide - AP30593CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Nicastrin Control Peptide - AP30594CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Nicastrin Control Peptide - SP5274CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Nicastrin Peptide - 3983P from ProSci Category Peptide Species Human

Nicastrin Peptide - 3985P from ProSci Category Peptide Species Human

Nicastrin fusion protein - Ag5137 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human NCSTN, His tagged - NCSTN-2316H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human NCSTN, His-tagged - NCSTN-1217H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Nicastrin (NCSTN) - RPC680Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Nicastrin (NCSTN) - RPC680Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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