NCSTN

Gene Symbol NCSTN
Entrez Gene 23385
Alt Symbol ATAG1874
Species Human
Gene Type protein-coding
Description nicastrin
Other Description anterior pharynx-defective 2
Swissprots Q92542 Q86VV5 Q5T207 Q5T208
Accessions EAW52720 EAW52721 EAW52722 Q92542 AF240468 AAG11412 AK296153 BAG58892 AK299142 BAG61194 AK310741 AK314764 BAG37302 AY359120 AAQ89478 BC047621 AAH47621 BC100024 CN429672 D87442 BAA13383 JF432369 ADZ15586 XM_005245053 XP_005245110 XM_011509363 XP_011507665 XM_011509364 XP_011507666 NM_001290184 NP_001277113 NM_001290186 NP_001277115 NM_015331 NP_056146
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11396676}.
Top Pathways Notch signaling pathway, Alzheimer's disease

nicastrin CRISPR/Cas9 KO Plasmid (h) - sc-402790 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin HDR Plasmid (h) - sc-402790-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin Double Nickase Plasmid (h) - sc-402790-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin Double Nickase Plasmid (h2) - sc-402790-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin CRISPR Activation Plasmid (h) - sc-402790-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin CRISPR Activation Plasmid (h2) - sc-402790-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin Lentiviral Activation Particles (h) - sc-402790-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin Lentiviral Activation Particles (h2) - sc-402790-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

nicastrin siRNA (h) - sc-36063 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

nicastrin shRNA Plasmid (h) - sc-36063-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

nicastrin shRNA (h) Lentiviral Particles - sc-36063-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nicastrin RNAi - H00023385-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU078021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15116 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15116 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NCSTN siRNA (Human) - CRH8229 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NCSTN (NM_015331.2) - SHH350240 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NCSTN(NM_015331.2) - SHR003486 from Creative biogene

Category siRNA
Species Reactivities Human

Nicastrin siRNA - orb219199 from Biorbyt

Category siRNA
Prices $417.00
Sizes 5 od (260 nm)
Species Reactivities Human

Human NCSTN siRNA - orb268731 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NCSTN shRNA Plasmid (Human) - CHH8229 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NCSTN miRNA 3'UTR clone - MiUTR1H-06690 from Creative biogene

Species Reactivities Human
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