NCSTN

Gene Symbol	NCSTN
Entrez Gene	23385
Alt Symbol	ATAG1874
Species	Human
Gene Type	protein-coding
Description	nicastrin
Other Description	anterior pharynx-defective 2
Swissprots	Q92542 Q86VV5 Q5T207 Q5T208
Accessions	EAW52720 EAW52721 EAW52722 Q92542 AF240468 AAG11412 AK296153 BAG58892 AK299142 BAG61194 AK310741 AK314764 BAG37302 AY359120 AAQ89478 BC047621 AAH47621 BC100024 CN429672 D87442 BAA13383 JF432369 ADZ15586 XM_005245053 XP_005245110 XM_011509363 XP_011507665 XM_011509364 XP_011507666 NM_001290184 NP_001277113 NM_001290186 NP_001277115 NM_015331 NP_056146
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11396676}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NCSTN gene - orb91676 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

Human-NCSTN-cDNA-Clone - DC07680 from Abgent, a WuXi AppTec company Prices $930.15 Sizes 10 µg Species Human Accession BC047621

NCSTN - MBS1266872 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC047621

Human NCSTN cDNA clone(NM_015331.2) - CDFH012284 from Creative Biomart Species Human Accession NM_015331.2

Human NCSTN ORF clone(NM_015331.2) - CDCL185440 from Creative Biomart Species Human Accession NM_015331.2

Human NCSTN ORF clone(NM_015331.2) - CDCL185441 from Creative Biomart Species Human Accession NM_015331.2

Human NCSTN ORF Clone(NM_015331.2) - CDCR299312 from Creative Biomart Species Human Accession NM_015331.2

Human NCSTN ORF Clone(NM_015331.2) - CDCR299313 from Creative Biomart Species Human Accession NM_015331.2

Human Nicastrin/NCSTN Gene ORF cDNA clone in cloning vector - HG11183-M from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11183-NM from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, N-HA tag - HG11183-NY from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11183-CF from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, N-His tag - HG11183-NH from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11183-CM from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, C-His tag - HG11183-CH from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, C-HA tag - HG11183-CY from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11183-ACR from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid - HG11183-UT from Sino Biological Species Human

Human NCSTN Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11183-M-F from Sino Biological Species Human Accession NM_015331.2

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11183-ACG from Sino Biological Species Human

Human Nicastrin/NCSTN Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11183-NF from Sino Biological Species Human

Human NCSTN ORF clone(NM_015331.2) - CDCL185440 from Creative biogene Species Human

Human NCSTN ORF Clone (BC047621) - CDCS413930 from Creative biogene Species Human Accession Q92542

Human NCSTN cDNA Clone(NM_015331.2) - CDFH012284 from Creative biogene Species Human

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