NCSTN

Gene Symbol	NCSTN
Entrez Gene	23385
Alt Symbol	ATAG1874
Species	Human
Gene Type	protein-coding
Description	nicastrin
Other Description	anterior pharynx-defective 2
Swissprots	Q92542 Q86VV5 Q5T207 Q5T208
Accessions	EAW52720 EAW52721 EAW52722 Q92542 AF240468 AAG11412 AK296153 BAG58892 AK299142 BAG61194 AK310741 AK314764 BAG37302 AY359120 AAQ89478 BC047621 AAH47621 BC100024 CN429672 D87442 BAA13383 JF432369 ADZ15586 XM_005245053 XP_005245110 XM_011509363 XP_011507665 XM_011509364 XP_011507666 NM_001290184 NP_001277113 NM_001290186 NP_001277115 NM_015331 NP_056146
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11396676}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NCSTN 293T Cell Transient Overexpression Lysate(Denatured) - H00023385-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

NCSTN overexpression lysate - LY414628 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

NCSTN 293 Cell Lysate - 407006 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Nicastrin Overexpression Lysate (Denatured) - H00023385-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

NCSTN Over-expression Lysate Product - GWB-AD62B6 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human Nicastrin / NCSTN HEK293 Cell Lysate (WB positive control) - 11183-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human NCSTN Human Cells Transfected Lysate (positive control) (denatured) - orb173299 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Nicastrin Overexpression Lysate (Native) - NBP2-10287 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Nicastrin Overexpression Lysate (Denatured) - H00023385-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human NCSTN Knockdown Stable Cell Line - CSC-DC010208 from Creative biogene Category Cell Line Species Human

Human NCSTN Knockout Cell Line-HEK293T - CSC-RT1070 from Creative biogene Category Cell Line Species Human

NCSTN KO Cell Lysate-HEK293T - CLKO-0560 from Creative biogene Category Cell Lysate

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