| Gene Symbol |
TFEC
|
| Entrez Gene |
22797
|
| Alt Symbol |
TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor EC
|
| Other Description |
class E basic helix-loop-helix protein 34
|
| Swissprots |
B2R8X5 Q8N6J9 Q709A4 O14948 Q5H9U8
|
| Accessions |
AAS02009 AAS07449 EAL24366 EAW83490 EAW83491 EAW83492 O14948 AJ608795 CAE77680 AK301479 BAH13493 AK313546 BAG36322 BC029891 AAH29891 BX538223 CR933605 CAI45926 D43945 BAA21908 XM_011515963 XP_011514265 XM_011515964 XP_011514266 XM_011515965 XP_011514267 XM_011515966 XP_011514268 XM_011515967 XP_011514269 XM_011515968 XP_011514270 XM_011515969 XP_011514271 XM_011515970 XP_011514272 XM_011515971 XP_011514273 XM_011515972 XP_011514274 XM_011515973 XP_011514275 XM_011515974 XP_011514276 NM_001018058 NP_001018068 NM_001244583 NP_001231512 NM_012252 NP_036384
|
| Function |
Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:9256061}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11467950}.
|
| Tissue Specificity |
Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon. {ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:15118077}.
|