TFEC
| Gene Symbol | TFEC |
|---|---|
| Entrez Gene | 22797 |
| Alt Symbol | TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L |
| Species | Human |
| Gene Type | protein-coding |
| Description | transcription factor EC |
| Other Description | class E basic helix-loop-helix protein 34 |
| Swissprots | B2R8X5 Q8N6J9 Q709A4 O14948 Q5H9U8 |
| Accessions | AAS02009 AAS07449 EAL24366 EAW83490 EAW83491 EAW83492 O14948 AJ608795 CAE77680 AK301479 BAH13493 AK313546 BAG36322 BC029891 AAH29891 BX538223 CR933605 CAI45926 D43945 BAA21908 XM_011515963 XP_011514265 XM_011515964 XP_011514266 XM_011515965 XP_011514267 XM_011515966 XP_011514268 XM_011515967 XP_011514269 XM_011515968 XP_011514270 XM_011515969 XP_011514271 XM_011515970 XP_011514272 XM_011515971 XP_011514273 XM_011515972 XP_011514274 XM_011515973 XP_011514275 XM_011515974 XP_011514276 NM_001018058 NP_001018068 NM_001244583 NP_001231512 NM_012252 NP_036384 |
| Function | Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250, ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:9256061}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11467950}. |
| Tissue Specificity | Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon. {ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:15118077}. |
TFEC CRISPR/Cas9 KO Plasmid (h) - sc-406102 from Santa Cruz Biotechnology
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TFEC HDR Plasmid (h) - sc-406102-HDR from Santa Cruz Biotechnology
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TFEC Double Nickase Plasmid (h) - sc-406102-NIC from Santa Cruz Biotechnology
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TFEC Double Nickase Plasmid (h2) - sc-406102-NIC-2 from Santa Cruz Biotechnology
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TFEC CRISPR Activation Plasmid (h) - sc-406102-ACT from Santa Cruz Biotechnology
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TFEC CRISPR Activation Plasmid (h2) - sc-406102-ACT-2 from Santa Cruz Biotechnology
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TFEC Lentiviral Activation Particles (h) - sc-406102-LAC from Santa Cruz Biotechnology
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TFEC Lentiviral Activation Particles (h2) - sc-406102-LAC-2 from Santa Cruz Biotechnology
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TFEC siRNA (h) - sc-38511 from Santa Cruz Biotechnology
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TFEC shRNA Plasmid (h) - sc-38511-SH from Santa Cruz Biotechnology
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TFEC shRNA (h) Lentiviral Particles - sc-38511-V from Santa Cruz Biotechnology
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TFEC RNAi - H00022797-R01 from Novus Biologicals
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TFEC RNAi - H00022797-R02 from Novus Biologicals
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MISSION® esiRNA - EHU066721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21258 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21258 from Sigma-Aldrich
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TFEC siRNA (Human) - CRH7777 from Cohesion Biosciences
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TFEC - MBS8224736 from MyBioSource
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TFEC CRISPR/Cas9 KO Plasmid (h2) - sc-406102-KO-2 from Santa Cruz Biotechnology
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TFEC HDR Plasmid (h2) - sc-406102-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TFEC (NM_012252.3) - SHH426208 from Creative biogene
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Human TFEC siRNA - orb268279 from Biorbyt
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TFEC shRNA Plasmid (Human) - CHH7777 from Cohesion Biosciences
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