| Gene Symbol |
UGT1A6
|
| Entrez Gene |
54578
|
| Alt Symbol |
GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A6
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A6|UDP-glucuronosyltransferase 1 family polypeptide A6s|UDP-glucuronosyltransferase 1-6|UDP-glucuronosyltransferase 1-F|UDP-glucuronosyltransferase 1A6|UGT-1F|UGT1*6|UGT1-06|UGT1.6|phenol-metabolizing UDP-glucuronosyltransferase
|
| Swissprots |
P19224 A6NKK6 Q96TE7 B8K289
|
| Accessions |
AAA61247 AAB87411 AAC41717 AAG30420 EAW71055 P19224 AY435141 AAR95642 BC011409 BC019861 AAH19861 BE463503 BM688740 BM924331 DB014621 DQ364250 ABC96774 J04093 AAA61251 NM_001072 NP_001063 NM_205862 NP_995584
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:18004212}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|
![Western Blot: UGT1A6 Overexpression Lysate (Adult Normal) [NBL1-17598] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UGT1A6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2923_UGT1A6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17598-img0002.jpg)