UGT1A6
| Gene Symbol | UGT1A6 |
|---|---|
| Entrez Gene | 54578 |
| Alt Symbol | GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F |
| Species | Human |
| Gene Type | protein-coding |
| Description | UDP glucuronosyltransferase 1 family, polypeptide A6 |
| Other Description | UDP glycosyltransferase 1 family, polypeptide A6|UDP-glucuronosyltransferase 1 family polypeptide A6s|UDP-glucuronosyltransferase 1-6|UDP-glucuronosyltransferase 1-F|UDP-glucuronosyltransferase 1A6|UGT-1F|UGT1*6|UGT1-06|UGT1.6|phenol-metabolizing UDP-glucuronosyltransferase |
| Swissprots | P19224 A6NKK6 Q96TE7 B8K289 |
| Accessions | AAA61247 AAB87411 AAC41717 AAG30420 EAW71055 P19224 AY435141 AAR95642 BC011409 BC019861 AAH19861 BE463503 BM688740 BM924331 DB014621 DQ364250 ABC96774 J04093 AAA61251 NM_001072 NP_001063 NM_205862 NP_995584 |
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}. |
| Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:18004212}. |
| Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
Human UGT1A6 full length protein - ab162788 from Abcam
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Human UGT1A6 protein fragment - ab162789 from Abcam
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Recombinant Human UGT1A6 Protein - H00054578-P01 from Novus Biologicals
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Recombinant Human UGT1A6 Protein - H00054578-Q01 from Novus Biologicals
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UGT1A6-Antibody-N-term-Blocking-Peptide - BP19550a from Abgent, a WuXi AppTec company
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UGT1A6 Protein Lysate (APL10368) - APL10368 from Aviva Systems Biology
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UGT1A6 Protein Lysate (APL10369) - APL10369 from Aviva Systems Biology
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UGT1A6 Protein Lysate (APL10370) - APL10370 from Aviva Systems Biology
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UGT1A6 Blocking Peptide - 33R-1424 from Fitzgerald
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UGT1A6 - H00054578-P01 from Acris Antibodies
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UGT1A6 - H00054578-Q01-10 from Acris Antibodies
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UGT1A6 - H00054578-Q01-25 from Acris Antibodies
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UGT1A6 fusion protein - ag3792 from Proteintech Group
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Recombinant Human UGT1A6 - UGT1A6-31663TH from Creative Biomart
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Recombinant Human UGT1A6, GST-tagged - UGT1A6-208H from Creative Biomart
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UGT1A6 fusion protein - Ag20635 from Proteintech Group
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UGT1A6 Protein Lysate - orb333299 from Biorbyt
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UGT1A6 Protein Lysate - orb333298 from Biorbyt
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UGT1A6 Recombinant Protein Antigen - NBP2-49113PEP from Novus Biologicals
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UGT1A6 Protein Lysate - orb333300 from Biorbyt
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Recombinant Human UGT1A6 protein, MYC/DDK-tagged - UGT1A6-12H from Creative Biomart
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