SIRT4

Gene Symbol SIRT4
Entrez Gene 23409
Alt Symbol SIR2L4
Species Human
Gene Type protein-coding
Description sirtuin 4
Other Description NAD-dependent ADP-ribosyltransferase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4|SIR2-like protein 4|regulatory protein SIR2 homolog 4|sir2-like 4|sirtuin type 4
Swissprots O43346 Q32M33 Q9Y6E7
Accessions AAB95634 CAL00158 CAL48200 CAN36294 EAW98182 EAW98183 Q9Y6E7 AF083109 AAD40852 BC034736 BC109319 AAI09320 BC109320 AAI09321 BP232525 XM_005253865 XP_005253922 XM_006719308 XP_006719371 XM_006719309 XP_006719372 NM_012240 NP_036372
Function Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127, ECO:0000269|PubMed:235623
Subcellular Location Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127}.
Tissue Specificity Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. {ECO:0000269|PubMed:10381378}.

SIRT4 (H-234) - sc-135053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SIRT4 (H-234): sc-135053. Western blot analysis of SIRT4 expression in mouse liver tissue extract.

SIRT4 (F-18) - sc-66268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRT4 (F-18): sc-66268. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

SIRT4 (95.1) - sc-135797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SIRT4 (95.61) - sc-135798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

SIRT4 (P-20) - sc-66270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SIRT4 (N-20) - sc-66269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SIRT4 (S-18) - sc-66271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SIRT4 antibody - ab124508 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Anti-SIRT4 antibody (ab124508) at 1 µg/ml + Human liver tissue lysate at 15 µg

Anti-SIRT4 antibody - ab115517 from Abcam

Prices $378.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115517, at 2.5µg/ml, staining SIRT4 in formalin-fixed, paraffin-embedded Human skeletal muscle tissue by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SIRT4 antibody - ab124521 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT4 antibody (ab124521) at 4 µg/ml + Rat kidney tissue lysate

Anti-SIRT4 / Sirtuin 4 Antibody (aa302-314) IHC-plus™ - LS-B2493 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SIRT4 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2493 concentration 5 ug/ml.

Anti-SIRT4 / Sirtuin 4 Antibody (aa1-50) - LS-C10183 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa240-254) - LS-C3190 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody - LS-C153167 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody - LS-C183460 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa66-95, AP) - LS-C217520 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa66-95, APC) - LS-C217521 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa36-85) - LS-C109170 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SIRT4 antibody LS-C109170 Western blot of Fetal Heart lysate.

Anti-SIRT4 / Sirtuin 4 Antibody (aa66-95, Biotin) - LS-C217522 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa66-95, FITC) - LS-C217523 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa66-95, Azide-free, HRP) - LS-C217524 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa35-84) - LS-C109547 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SIRT4 antibody LS-C109547 Western blot of Fetal Small Intestine lysate.

Anti-SIRT4 / Sirtuin 4 Antibody (aa66-95, PE) - LS-C217525 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa26-333) - LS-C296447 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT4 / Sirtuin 4 Antibody (aa26-333, Biotin) - LS-C299640 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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