SIRT4

Gene Symbol	SIRT4
Entrez Gene	23409
Alt Symbol	SIR2L4
Species	Human
Gene Type	protein-coding
Description	sirtuin 4
Other Description	NAD-dependent ADP-ribosyltransferase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4|SIR2-like protein 4|regulatory protein SIR2 homolog 4|sir2-like 4|sirtuin type 4
Swissprots	O43346 Q32M33 Q9Y6E7
Accessions	AAB95634 CAL00158 CAL48200 CAN36294 EAW98182 EAW98183 Q9Y6E7 AF083109 AAD40852 BC034736 BC109319 AAI09320 BC109320 AAI09321 BP232525 XM_005253865 XP_005253922 XM_006719308 XP_006719371 XM_006719309 XP_006719372 NM_012240 NP_036372
Function	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127, ECO:0000269|PubMed:235623
Subcellular Location	Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127}.
Tissue Specificity	Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. {ECO:0000269|PubMed:10381378}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIRT4 full length protein - ab176942 from Abcam Category Protein Source E. coli Species Human

Human SIRT4 full length protein - ab101713 from Abcam Category Protein Source E. coli Species Human

Human SIRT4 peptide - ab186718 from Abcam Category Peptide

Human SIRT4 peptide - ab23185 from Abcam Category Peptide Species Human

Human SIRT4 protein fragment - ab79949 from Abcam Category Protein Source E. coli Species Human

SIRT4 / Sirtuin 4 Antibody Blocking Peptide - LS-E5673 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT4 / Sirtuin 4 Antibody Blocking Peptide - LS-E25687 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT4 / Sirtuin 4 Antibody Blocking Peptide - LS-E30934 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRT4 / Sirtuin 4 Antibody Blocking Peptide - LS-E11359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT4 / Sirtuin 4 Antibody Blocking Peptide - LS-E11373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT4 / Sirtuin 4 Antibody Blocking Peptide - LS-E11372 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SIRT4 Protein - H00023409-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SIRT4 Protein - H00023409-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SIRT4 Peptide - NBP1-76265PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SIRT4-Antibody-N-term-Blocking-Peptide - BP18208a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT4-Antibody-C-term-Blocking-Peptide - BP6243a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT4 blocking peptide - GTX89788-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

SIRT4 Blocking Peptide - 33R-7782 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIRT4 Blocking Peptide - 33R-10670 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SIRT4 Blocking Peptide - 33R-1521 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIRT4 Peptide - AC21-0517-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SIRT4 - H00023409-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SIRT4 - H00023409-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SIRT4 - H00023409-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SIRT4 control peptide - AP26212CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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