SIRT4

Gene Symbol	SIRT4
Entrez Gene	23409
Alt Symbol	SIR2L4
Species	Human
Gene Type	protein-coding
Description	sirtuin 4
Other Description	NAD-dependent ADP-ribosyltransferase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4|SIR2-like protein 4|regulatory protein SIR2 homolog 4|sir2-like 4|sirtuin type 4
Swissprots	O43346 Q32M33 Q9Y6E7
Accessions	AAB95634 CAL00158 CAL48200 CAN36294 EAW98182 EAW98183 Q9Y6E7 AF083109 AAD40852 BC034736 BC109319 AAI09320 BC109320 AAI09321 BP232525 XM_005253865 XP_005253922 XM_006719308 XP_006719371 XM_006719309 XP_006719372 NM_012240 NP_036372
Function	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127, ECO:0000269|PubMed:235623
Subcellular Location	Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127}.
Tissue Specificity	Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. {ECO:0000269|PubMed:10381378}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIRT4 / Sirtuin 4 ELISA Kit (Sandwich ELISA) - LS-F6800 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

NAD-dependent ADP-ribosyltransferase sirtuin-4 (SIRT4/SIR2L4), Human, ELISA Kit - CSB-E17016h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NAD-dependent ADP-ribosyltransferase sirtuin-4, SIRT4, Human, ELISA Kit - E0341h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Sirtuin 4 (SIRT4), Human, ELISA Kit - SEE914Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , ELISA Kit - MBS706224 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sirtuin 4 (SIRT4), ELISA Kit - MBS2020879 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.055ng/mL. Range 0.156-10ng/mL

ELISA Kit for Sirtuin 4 (SIRT4) - SEE914Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human NAD-dependent ADP-ribosyltransferase sirtuin-4 (SIRT4/SIR2L4) ELISA kit - CSB-E17016h from Cusabio Category ELISA Kit Sensitivity 1.56 pg/ml Range Request Information

ELISA Kit for Sirtuin 4 (SIRT4) - SEE914Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human SIRT4 / Sirtuin 4 ELISA Kit (Custom ELISA) - LS-F14345 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse SIRT4 / Sirtuin 4 ELISA Kit (Custom ELISA) - LS-F14344 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Bovine SIRT4 / Sirtuin 4 ELISA Kit (Custom ELISA) - LS-F14343 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Sirtuin 4 (SIRT4) ELISA Kit - EKU07355 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.055 ng/mL Range 0.156-10 ng/mL

Human NAD-dependent ADP-ribosyltransferase sirtuin-4 ELISA Kit - abx253817 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Sirtuin 4 ELISA Kit - abx153095 from Abbexa Category ELISA Kit Sensitivity 0.055 ng/ml Range 0.156 ng/ml - 10 ng/ml

Sirtuin 4 (SIRT4), Human, ELISA Kit - DL-SIRT4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human SIRT4 ELISA Kit - orb368248 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 0.156-10ng/mL Detection low threshold: 0.051ng/mL

Human SIRT4 ELISA Kit - abx570793 from Abbexa Category ELISA Kit Sensitivity 0.051 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human NAD-dependent ADP-ribosyltransferase sirtuin-4 (SIRT4/SIR2L4) ELISA Kit - EKC34726 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 1.56 pg/ml Range 6.25 pg/ml-400 pg/ml

Human NAD-dependent ADP-ribosyltransferase sirtuin-4 ELISA Kit - EKE53579 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.067 ng/mL Range 0.156-10 ng/mL

SIRT4 - EKH1722 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

SIRT4 ELISA Kit (Human) : 96 Wells (OKEH00386) - OKEH00386 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.067 ng/mL Range 0.156 - 10 ng/mL

Human SIRT4 ELISA Kit - E035347 from Biobool Category ELISA Kit

Human NAD-dependent ADP-ribosyltransferase sirtuin-4 ELISA Kit - EK1638 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.067ng/mL Range 0.156-10 ng/mL

anti-SIRT4 antibody - ARG63423 from Arigo Biolaboratories Category ELISA Kit

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