| Gene Symbol |
SIRT4
|
| Entrez Gene |
23409
|
| Alt Symbol |
SIR2L4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 4
|
| Other Description |
NAD-dependent ADP-ribosyltransferase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4|SIR2-like protein 4|regulatory protein SIR2 homolog 4|sir2-like 4|sirtuin type 4
|
| Swissprots |
O43346 Q32M33 Q9Y6E7
|
| Accessions |
AAB95634 CAL00158 CAL48200 CAN36294 EAW98182 EAW98183 Q9Y6E7 AF083109 AAD40852 BC034736 BC109319 AAI09320 BC109320 AAI09321 BP232525 XM_005253865 XP_005253922 XM_006719308 XP_006719371 XM_006719309 XP_006719372 NM_012240 NP_036372
|
| Function |
Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127, ECO:0000269|PubMed:235623
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127}.
|
| Tissue Specificity |
Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. {ECO:0000269|PubMed:10381378}.
|
![Western Blot: SIRT4 Overexpression Lysate (Adult Normal) [NBL1-15977] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SIRT4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5539_SIRT4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15977-img0002.jpg)