SIRT4

Gene Symbol	SIRT4
Entrez Gene	23409
Alt Symbol	SIR2L4
Species	Human
Gene Type	protein-coding
Description	sirtuin 4
Other Description	NAD-dependent ADP-ribosyltransferase sirtuin-4|NAD-dependent protein deacetylase sirtuin-4|SIR2-like protein 4|regulatory protein SIR2 homolog 4|sir2-like 4|sirtuin type 4
Swissprots	O43346 Q32M33 Q9Y6E7
Accessions	AAB95634 CAL00158 CAL48200 CAN36294 EAW98182 EAW98183 Q9Y6E7 AF083109 AAD40852 BC034736 BC109319 AAI09320 BC109320 AAI09321 BP232525 XM_005253865 XP_005253922 XM_006719308 XP_006719371 XM_006719309 XP_006719372 NM_012240 NP_036372
Function	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion. {ECO:0000255|HAMAP-Rule:MF_03161, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127, ECO:0000269|PubMed:235623
Subcellular Location	Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03161, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:17715127}.
Tissue Specificity	Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus. {ECO:0000269|PubMed:10381378}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIRT4 - MBS1268755 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC109319

Human SIRT4 ORF clone(NM_012240.2) - CDCL186201 from Creative Biomart Species Human Accession NM_012240.2

Human SIRT4 ORF Clone(NM_012240.2) - CDCL175516 from Creative Biomart Species Human Accession NM_012240.2

human SIRT4 ORF clone - CDCH080422 from Creative Biomart Species Human Accession NM_012240

human SIRT4 ORF clone - CDCH080423 from Creative Biomart Species Human Accession NM_012240

Human SIRT4 Gene ORF cDNA clone in cloning vector - HG13076-G from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid - HG11936-UT from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13076-ANG from Sino Biological Species Human

Human SIRT4 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-tagged - HG13076-CY from Sino Biological Species Human Accession NM_012240.2

Human SIRT4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13076-NF from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13076-NY from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13076-NM from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13076-CF from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13076-ACG from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, N-His tag - HG13076-NH from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13076-CM from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13076-ACR from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13076-ANR from Sino Biological Species Human

Human SIRT4 Gene ORF cDNA clone expression plasmid, C-His tag - HG13076-CH from Sino Biological Species Human

Human SIRT4 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG13076-G-F from Sino Biological Species Human Accession NM_012240.2

Human SIRT4 Gene ORF cDNA clone expression plasmid - HG13076-UT from Sino Biological Species Human

Human SIRT4 ORF clone(NM_012240.2) - CDCL186201 from Creative biogene Species Human

Human SIRT4 ORF Clone (BC109319) - CDCS413256 from Creative biogene Species Human Accession Q9Y6E7

Human SIRT4 gene - orb93450 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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