Gene Symbol | MYDGF |
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Entrez Gene | 56005 |
Alt Symbol | C19orf10, EUROIMAGE1875335, IL25, IL27, IL27w, R33729_1, SF20 |
Species | Human |
Gene Type | protein-coding |
Description | myeloid-derived growth factor |
Other Description | UPF0556 protein C19orf10|interleukin 25|interleukin 27 working designation|interleukin-25|stromal cell-derived growth factor SF20 |
Swissprots | Q9NP69 O75256 Q969H8 O75272 Q9BTK7 D6W628 |
Accessions | AAC27824 AAC33800 EAW69202 EAW69203 Q969H8 AF282264 AK098829 AL365373 CAB96947 AL365374 CAB96948 BC003639 AAH03639 BC010129 AAH10129 BC014655 AAH14655 BG484758 NM_019107 NP_061980 |
Function | Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250|UniProtKB:Q9CPT4, ECO:0000269|PubMed:25581518}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17362502}. Note=Secreted into blood plasma. {ECO:0000269|PubMed:25581518}. |
Tissue Specificity | Expressed in bone marrow cells (PubMed:25581518). Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties (PubMed:17362502). {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}. |
IL-25 (G-20) - sc-22148 from Santa Cruz Biotechnology
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IL-25 (M-15) - sc-22149 from Santa Cruz Biotechnology
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Anti-SF20 antibody - ab168129 from Abcam
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Anti-SF20 antibody [EPR13211] - ab181096 from Abcam
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Anti-MYDGF / SF20 Antibody (Biotin) - LS-C104568 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody - LS-C104831 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody (Biotin) - LS-C190407 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody - LS-C306619 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody (N-Terminus) - LS-C151585 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody - LS-C306620 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody (aa67-116) - LS-C151584 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody - LS-C331255 from LifeSpan Bioscience
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Anti-MYDGF / SF20 Antibody - LS-C192366 from LifeSpan Bioscience
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IL25 Antibody (2D4) - H00056005-M03 from Novus Biologicals
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IL25 Antibody - H00056005-B01P from Novus Biologicals
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Anti-C19orf10 antibody produced in rabbit - HPA046744 from Sigma-Aldrich
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Monoclonal Anti-C19orf10 antibody produced in mouse - WH0056005M3 from Sigma-Aldrich
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Anti-C19ORF10 antibody produced in mouse - SAB1407720 from Sigma-Aldrich
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C19orf10 antibody - middle region (ARP63969_P050) - ARP63969_P050 from Aviva Systems Biology
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C19orf10 antibody - N-terminal region (ARP63970_P050) - ARP63970_P050 from Aviva Systems Biology
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C19orf10-Antibody-monoclonal-M03 - AT1332a from Abgent, a WuXi AppTec company
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IL27 antibody - GTX54307 from GeneTex
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IL27 antibody [N1C3-2] - GTX119293 from GeneTex
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Anti -C19orf10 (C19orf10, Chromosome 19 Open Reading Frame 10, CS010, EUROIMAGE1875335, IL25, IL 27, IL-25, IL25, IL27, IL27w, Interleukin 25, Interleukin 27 working designation,Interleukin-25, Interleukin25, R33729 1, R337291, SF20, Stromal Cell derived Grow - 221212 from USBiological Life Science
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Anti -C19orf10 (UPF0556 Protein C19orf10, Interleukin-25, IL-25, Stromal Cell-derivedGrowth Factor SF20, IL25, IL27, IL-27, IL27w, R33729_1, SF20) - 209824 from USBiological Life Science
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