| Gene Symbol |
PREX1
|
| Entrez Gene |
57580
|
| Alt Symbol |
P-REX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
|
| Other Description |
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein|ptdIns(3,4,5)-dependent Rac exchanger 1
|
| Swissprots |
Q9UGQ4 Q9H4Q6 Q5JS96 E1P5X9 Q9BQH0 Q9P2D2 Q7Z2L9 Q5JS95 Q8TCU6 Q69YL2 Q9BX55
|
| Accessions |
EAW75684 EAW75685 EAW75686 Q8TCU6 AB037836 BAA92653 AJ320261 CAC86401 AK090860 AL136579 CAB66514 AL832913 CAH10614 BC009948 BC053616 AAH53616 BC156402 AAI56403 XM_005260471 XP_005260528 XM_011528934 XP_011527236 XM_011528935 XP_011527237 NM_020820 NP_065871
|
| Function |
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
|
| Tissue Specificity |
Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
|
| Top Pathways |
Chemokine signaling pathway
|