PREX1

Gene Symbol PREX1
Entrez Gene 57580
Alt Symbol P-REX1
Species Human
Gene Type protein-coding
Description phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Other Description phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein|ptdIns(3,4,5)-dependent Rac exchanger 1
Swissprots Q9UGQ4 Q9H4Q6 Q5JS96 E1P5X9 Q9BQH0 Q9P2D2 Q7Z2L9 Q5JS95 Q8TCU6 Q69YL2 Q9BX55
Accessions EAW75684 EAW75685 EAW75686 Q8TCU6 AB037836 BAA92653 AJ320261 CAC86401 AK090860 AL136579 CAB66514 AL832913 CAH10614 BC009948 BC053616 AAH53616 BC156402 AAI56403 XM_005260471 XP_005260528 XM_011528934 XP_011527236 XM_011528935 XP_011527237 NM_020820 NP_065871
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Subcellular Location Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Tissue Specificity Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Top Pathways Chemokine signaling pathway

P-Rex1 CRISPR/Cas9 KO Plasmid (h) - sc-405984 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 HDR Plasmid (h) - sc-405984-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 Double Nickase Plasmid (h) - sc-405984-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 Double Nickase Plasmid (h2) - sc-405984-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 CRISPR Activation Plasmid (h) - sc-405984-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 CRISPR Activation Plasmid (h2) - sc-405984-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 Lentiviral Activation Particles (h) - sc-405984-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 Lentiviral Activation Particles (h2) - sc-405984-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

P-Rex1 siRNA (h) - sc-76023 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

P-Rex1 shRNA Plasmid (h) - sc-76023-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

P-Rex1 shRNA (h) Lentiviral Particles - sc-76023-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU136571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17392 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17392 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09877 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09877

PREX1 siRNA (Human) - CRJ1555 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PREX1 (NM_020820.3) - SHH382444 from Creative biogene

Category siRNA
Species Reactivities Human

Human PREX1 siRNA - orb272056 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PREX1 shRNA Plasmid (Human) - CHJ1555 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PREX1 miRNA 3'UTR clone - MiUTR1H-08245 from Creative biogene

Species Reactivities Human
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