PREX1

Gene Symbol PREX1
Entrez Gene 57580
Alt Symbol P-REX1
Species Human
Gene Type protein-coding
Description phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Other Description phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein|ptdIns(3,4,5)-dependent Rac exchanger 1
Swissprots Q9UGQ4 Q9H4Q6 Q5JS96 E1P5X9 Q9BQH0 Q9P2D2 Q7Z2L9 Q5JS95 Q8TCU6 Q69YL2 Q9BX55
Accessions EAW75684 EAW75685 EAW75686 Q8TCU6 AB037836 BAA92653 AJ320261 CAC86401 AK090860 AL136579 CAB66514 AL832913 CAH10614 BC009948 BC053616 AAH53616 BC156402 AAI56403 XM_005260471 XP_005260528 XM_011528934 XP_011527236 XM_011528935 XP_011527237 NM_020820 NP_065871
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Subcellular Location Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.
Tissue Specificity Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Top Pathways Chemokine signaling pathway

PREX1 (D8O8D) Rabbit mAb - 13168 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8O8D
Western blot analysis of extracts from various cell lines using PREX1 (D8O8D) Rabbit mAb (upper) or GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower). Differential expression of PREX1 in breast cancer cells is consistent with that described by Sosa, M.S. et al. (2010).

P-Rex1 (D-20) - sc-85805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

P-Rex1 (K-19) - sc-85806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P-Rex1 (K-19): sc-85806. Western blot analysis of P-Rex1 expression in HeLa whole cell lysate.

Anti-PREX1 antibody - ab124231 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PREX1 antibody - ab183638 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PREX1 antibody (ab183638) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg

Anti-PREX1 antibody - ab183643 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PREX1 antibody (ab183643) at 1/10000 dilutionLane 1 : 293T whole cell lysateLane 2 : 293T transfected with PREX1 whole cell lysateLysates/proteins at 1 µg per lane.

Anti-PREX1 antibody - ab102739 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PREX1 antibody (ab102739) at 1/100 dilution + MCF7 cell line lysate at 35 µg

Anti-PREX1 antibody - ab112950 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PREX1 antibody (ab112950) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-PREX1 antibody - ab99425 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-PREX1 antibody (ab99425) at 1 µg/ml + Human temporal cortex lysate at 35 µg

Anti-PREX1 / P-REX1 Antibody (aa1134-1163, AP) - LS-C239428 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa1134-1163, Biotin) - LS-C239430 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa1134-1163, APC) - LS-C239429 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa1134-1163, FITC) - LS-C239431 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594, AP) - LS-C239433 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa1134-1163, PE) - LS-C239432 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594, APC) - LS-C239434 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594, Biotin) - LS-C239435 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594, PE) - LS-C239439 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa1134-1163, Azide-free, HRP) - LS-C248549 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594, FITC) - LS-C239436 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594) - LS-C162135 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of PREX1 Antibody in MCF-7 cell line lysates (35 ug/lane). PREX1 (arrow) was detected using the purified antibody.

Anti-PREX1 / P-REX1 Antibody (aa1133-1163) - LS-C324286 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa567-594, Azide-free, HRP) - LS-C248550 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa573-602) - LS-C324289 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PREX1 / P-REX1 Antibody (aa1134-1163) - LS-C162134 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PREX1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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