CISD2

Gene Symbol CISD2
Entrez Gene 493856
Alt Symbol ERIS, Miner1, NAF-1, WFS2, ZCD2
Species Human
Gene Type protein-coding
Description CDGSH iron sulfur domain 2
Other Description CDGSH iron-sulfur domain-containing protein 2|endoplasmic reticulum intermembrane small protein|mitoNEET-related 1 protein|nutrient-deprivation autophagy factor-1|zinc finger, CDGSH-type domain 2
Swissprots Q7Z3D5 Q8N5K1
Accessions EAX06148 EAX06149 Q8N5K1 AA424361 AI277147 AK292134 BAF84823 AM392809 CAL37687 AM393385 CAL38263 BC020831 BC032300 AAH32300 BX537971 CAD97935 DB351048 DB565768 DN993861 NM_001008388 NP_001008389
Function Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269|PubMed:17846994, ECO:0000269|PubMed:20010695}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
Tissue Specificity Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets. {ECO:0000269|PubMed:17846994}.

ERIS (E-15) - sc-242636 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ERIS (L-18) - sc-242634 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CISD2 antibody - ab167109 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-CISD2 antibody (ab167109) at 1 µg/mlLane 2 : Anti-CISD2 antibody (ab167109) at 2 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-NAF-1 / CISD2 Antibody - LS-C335554 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CISD2 antibody.

Anti-NAF-1 / CISD2 Antibody (N-Terminus) - LS-C82478 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.

Anti-NAF-1 / CISD2 Antibody (Internal) IHC-plus™ - LS-B10097 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NAF-1 / CISD2 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10097 concentration 20 ug/ml.

CISD2 Antibody - NBP1-84809 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CISD2 Antibody [NBP1-84809] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Negative control (vector only transfected HEK293T lysate)Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY423415)

CISD2 Antibody - NBP1-59676 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CISD2 antibody produced in rabbit - HPA015914 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CISD2: <B>Cat. No. HPA015914</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Anti-CISD2 antibody produced in rabbit - AV44552 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: transfected 293T (<B>Cat. No. AV44552</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type transfected 293T

Anti-CISD2 antibody produced in rabbit - SAB3500866 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>CISD2 Antibody: <B>Cat. No. SAB3500866</B>: Western blot analysis of CISD2 in Rat brain tissue lysate with CISD2 antibody at (A) 1 and (B) 2 μg/mL.

CISD2 antibody - N-terminal region (ARP44552_P050) - ARP44552_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CISD2 antibody, N-term - GTX46690 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-CISD2 antibody, N-term used in Western blot. GTX46690

Naf1 antibody - 10R-6671 from Fitzgerald

Prices $150.00, $375.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C4

CISD2 antibody - 70R-16427 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

CISD2 antibody - 70R-6583 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

CISD2 Polyclonal Antibody - A5231 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cells, using CISD2 antibody.

CISD2 Antibody - abx004018 from Abbexa

Prices $490.00, $490.00, $490.00, $490.00
Sizes 10 μl, 50 μl, 100 μl, 200 μl
Host Rabbit
Clonality Polyclonal

CISD2 antibody - 13318-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded H-kidney(glomerulus) using 13318-1-AP(CISD2 Antibody) at Dilution 1:100 (under 10x lens)

CISD2 antibody - 66082-1-Ig from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Mouse
Clonality Monoclonal
Clone 3D7A3
Immunohistochemical of paraffin-embedded human kidney using 66082-1-Ig(CISD2-Specific antibody) at dilution of 1:50 (under 40x lens)

Anti-CISD2, Polyclonal Antibody - 25-A5231 from ARP American Research Products

Prices $279.00, $549.00
Sizes 50 µg, 200 µg
Host Rabbit
Clonality Polyclonal

Anti-TMEM173, Polyclonal Antibody - 25-A3575 from ARP American Research Products

Prices $299.00, $449.00
Sizes 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

CISD2 Antibody - 7301 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of CISD2 in rat brain tissue lysate with CISD2 antibody at (A) 1 and (B) 2 μg/m

CISD2 Antibody - 25-975 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Transfected 293T at 0.2-1 ug/ml.
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