| Gene Symbol |
CISD2
|
| Entrez Gene |
493856
|
| Alt Symbol |
ERIS, Miner1, NAF-1, WFS2, ZCD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDGSH iron sulfur domain 2
|
| Other Description |
CDGSH iron-sulfur domain-containing protein 2|endoplasmic reticulum intermembrane small protein|mitoNEET-related 1 protein|nutrient-deprivation autophagy factor-1|zinc finger, CDGSH-type domain 2
|
| Swissprots |
Q7Z3D5 Q8N5K1
|
| Accessions |
EAX06148 EAX06149 Q8N5K1 AA424361 AI277147 AK292134 BAF84823 AM392809 CAL37687 AM393385 CAL38263 BC020831 BC032300 AAH32300 BX537971 CAD97935 DB351048 DB565768 DN993861 NM_001008388 NP_001008389
|
| Function |
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. {ECO:0000269|PubMed:17846994, ECO:0000269|PubMed:20010695}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
|
| Tissue Specificity |
Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets. {ECO:0000269|PubMed:17846994}.
|
![Western Blot: CISD2 Overexpression Lysate (Adult Normal) [NBL1-09215] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CISD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4517_CISD2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09215-img0002.jpg)