| Gene Symbol |
KLKB1
|
| Entrez Gene |
3818
|
| Alt Symbol |
KLK3, PPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kallikrein B, plasma (Fletcher factor) 1
|
| Other Description |
Fletcher factor|kininogenin|plasma kallikrein|plasma kallikrein heavy chain|plasma kallikrein light chain|plasma prekallikrein
|
| Swissprots |
Q4W5C3 Q17RE8 A6NH96 B2R8H9 P03952 Q17RE9
|
| Accessions |
AAF79940 AAN84794 AAY40900 EAX04622 EAX04623 P03952 AK292624 BAF85313 AK297672 BAG60034 AK313378 BAG36176 AW182528 BC117349 AAI17350 BC117351 AAI17352 BC143911 CN265612 HQ258334 ADR83088 M13143 AAA60153 XM_011531930 XP_011530232 XM_011531931 XP_011530233 XM_011531932 XP_011530234 XM_011531933 XP_011530235 XM_011531934 XP_011530236 NM_000892 NP_000883
|
| Function |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Complement and coagulation cascades
|
![Western Blot: Plasma Kallikrein 1B Overexpression Lysate (Adult Normal) [NBL1-12359] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Plasma Kallikrein 1B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3716_Plasma%2520Kallikrein%25201B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12359-img0002.jpg)