KLKB1

Gene Symbol KLKB1
Entrez Gene 3818
Alt Symbol KLK3, PPK
Species Human
Gene Type protein-coding
Description kallikrein B, plasma (Fletcher factor) 1
Other Description Fletcher factor|kininogenin|plasma kallikrein|plasma kallikrein heavy chain|plasma kallikrein light chain|plasma prekallikrein
Swissprots Q4W5C3 Q17RE8 A6NH96 B2R8H9 P03952 Q17RE9
Accessions AAF79940 AAN84794 AAY40900 EAX04622 EAX04623 P03952 AK292624 BAF85313 AK297672 BAG60034 AK313378 BAG36176 AW182528 BC117349 AAI17350 BC117351 AAI17352 BC143911 CN265612 HQ258334 ADR83088 M13143 AAA60153 XM_011531930 XP_011530232 XM_011531931 XP_011530233 XM_011531932 XP_011530234 XM_011531933 XP_011530235 XM_011531934 XP_011530236 NM_000892 NP_000883
Function The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Subcellular Location Secreted.
Top Pathways Complement and coagulation cascades

plasma kallikrein CRISPR/Cas9 KO Plasmid (h) - sc-402237 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein HDR Plasmid (h) - sc-402237-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein Double Nickase Plasmid (h) - sc-402237-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein Double Nickase Plasmid (h2) - sc-402237-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein CRISPR Activation Plasmid (h) - sc-402237-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein CRISPR Activation Plasmid (h2) - sc-402237-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein Lentiviral Activation Particles (h) - sc-402237-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein Lentiviral Activation Particles (h2) - sc-402237-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plasma kallikrein siRNA (h) - sc-40411 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

plasma kallikrein shRNA Plasmid (h) - sc-40411-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

plasma kallikrein shRNA (h) Lentiviral Particles - sc-40411-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU049271 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1838 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1838 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01845 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01845

KLKB1 siRNA (Human) - CRH2587 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KLKB1 (NM_000892.3) - SHH326660 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KLKB1(NM_000892.3) - SHL202670 from Creative biogene

Category siRNA
Species Reactivities Human

Human KLKB1 siRNA - orb263089 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KLKB1 shRNA Plasmid (Human) - CHH2587 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KLKB1 miRNA 3'UTR clone - MiUTR1H-05409 from Creative biogene

Species Reactivities Human
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