VAC14

Gene Symbol	VAC14
Entrez Gene	55697
Alt Symbol	ArPIKfyve, TAX1BP2, TRX
Species	Human
Gene Type	protein-coding
Description	Vac14 homolog (S. cerevisiae)
Other Description	Tax1 (human T-cell leukemia virus type I) binding protein 1|Tax1 (human T-cell leukemia virus type I) binding protein 2|protein VAC14 homolog|tax1-binding protein 2
Swissprots	B3KSM8 Q9BW96 Q6IA12 Q9H6V6 B3KPJ5 Q13174 Q08AM6 Q7L4Y1
Accessions	EAW51791 EAW51792 EAW51793 EAW51794 EAW51795 Q08AM6 AK001167 BAA91530 AK025479 BAB15145 AK056433 BAG51707 AK090627 AK093941 BAG52790 AK128439 AK297564 BAG59956 AK307766 AK310466 AL137396 CAB70724 BC000536 AAH00536 BC007214 AAH07214 BC110072 BC110852 BC125108 AAI25109 BC125109 AAI25110 CR457343 CAG33624 U25801 AAB03813 XM_005256038 XP_005256095 XM_005256041 XP_005256098 XM_011523223 XP_011521525 XM_011523224 XP_011521526 XM_011523225 XP_011521527 NM_018052 NP_060522
Function	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}.
Subcellular Location	Endosome membrane {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8611628}.
Top Pathways	HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VAC14 293T Cell Transient Overexpression Lysate(Denatured) - H00055697-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

VAC14 Overexpression Lysate (Denatured) - H00055697-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

VAC14 Overexpression Lysate (Native) - NBP2-06882 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human VAC14 Knockdown Stable Cell Line - CSC-DC017224 from Creative biogene Category Cell Line Species Human

VAC14 Knockout Cell Line-HeLa - CSC-RT1775 from Creative biogene Category Cell Line Species Human

VAC14 KO Cell Lysate-HeLa - CLKO-1623 from Creative biogene Category Cell Lysate

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