VAC14

Gene Symbol VAC14
Entrez Gene 55697
Alt Symbol ArPIKfyve, TAX1BP2, TRX
Species Human
Gene Type protein-coding
Description Vac14 homolog (S. cerevisiae)
Other Description Tax1 (human T-cell leukemia virus type I) binding protein 1|Tax1 (human T-cell leukemia virus type I) binding protein 2|protein VAC14 homolog|tax1-binding protein 2
Swissprots B3KSM8 Q9BW96 Q6IA12 Q9H6V6 B3KPJ5 Q13174 Q08AM6 Q7L4Y1
Accessions EAW51791 EAW51792 EAW51793 EAW51794 EAW51795 Q08AM6 AK001167 BAA91530 AK025479 BAB15145 AK056433 BAG51707 AK090627 AK093941 BAG52790 AK128439 AK297564 BAG59956 AK307766 AK310466 AL137396 CAB70724 BC000536 AAH00536 BC007214 AAH07214 BC110072 BC110852 BC125108 AAI25109 BC125109 AAI25110 CR457343 CAG33624 U25801 AAB03813 XM_005256038 XP_005256095 XM_005256041 XP_005256098 XM_011523223 XP_011521525 XM_011523224 XP_011521526 XM_011523225 XP_011521527 NM_018052 NP_060522
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}.
Subcellular Location Endosome membrane {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:8611628}.
Top Pathways HTLV-I infection, Viral carcinogenesis

VAC14 CRISPR/Cas9 KO Plasmid (h) - sc-408584 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 HDR Plasmid (h) - sc-408584-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 Double Nickase Plasmid (h) - sc-408584-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 Double Nickase Plasmid (h2) - sc-408584-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 CRISPR Activation Plasmid (h) - sc-408584-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 CRISPR Activation Plasmid (h2) - sc-408584-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 Lentiviral Activation Particles (h) - sc-408584-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 Lentiviral Activation Particles (h2) - sc-408584-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VAC14 siRNA (h) - sc-72206 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VAC14 shRNA Plasmid (h) - sc-72206-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VAC14 shRNA (h) Lentiviral Particles - sc-72206-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU151391 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN22629 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22629 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04298 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04298

VAC14 siRNA (Human) - CRJ0841 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VAC14 - MBS827808 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human VAC14(NM_018052.3) - SHL120698 from Creative biogene

Category siRNA
Species Reactivities Human

Human VAC14 siRNA - orb271342 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VAC14 shRNA Plasmid (Human) - CHJ0841 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VAC14 miRNA 3'UTR clone - MiUTR1H-11087 from Creative biogene

Species Reactivities Human
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