VAC14

Gene Symbol	VAC14
Entrez Gene	55697
Alt Symbol	ArPIKfyve, TAX1BP2, TRX
Species	Human
Gene Type	protein-coding
Description	Vac14 homolog (S. cerevisiae)
Other Description	Tax1 (human T-cell leukemia virus type I) binding protein 1|Tax1 (human T-cell leukemia virus type I) binding protein 2|protein VAC14 homolog|tax1-binding protein 2
Swissprots	B3KSM8 Q9BW96 Q6IA12 Q9H6V6 B3KPJ5 Q13174 Q08AM6 Q7L4Y1
Accessions	EAW51791 EAW51792 EAW51793 EAW51794 EAW51795 Q08AM6 AK001167 BAA91530 AK025479 BAB15145 AK056433 BAG51707 AK090627 AK093941 BAG52790 AK128439 AK297564 BAG59956 AK307766 AK310466 AL137396 CAB70724 BC000536 AAH00536 BC007214 AAH07214 BC110072 BC110852 BC125108 AAI25109 BC125109 AAI25110 CR457343 CAG33624 U25801 AAB03813 XM_005256038 XP_005256095 XM_005256041 XP_005256098 XM_011523223 XP_011521525 XM_011523224 XP_011521526 XM_011523225 XP_011521527 NM_018052 NP_060522
Function	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}.
Subcellular Location	Endosome membrane {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:8611628}.
Top Pathways	HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VAC14 full length protein - ab132729 from Abcam Category Protein Source Wheat germ Species Human

VAC14 / TRX Antibody Blocking Peptide - LS-E22538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VAC14 Recombinant Protein - H00055697-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human VAC14 Protein - H00055697-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Thioredoxin 1 protein - 30R-3006 from Fitzgerald Category Protein Prices $245.00 Sizes 500 µg Source E.coli

Thioredoxin 2 protein - 30R-3015 from Fitzgerald Category Protein Prices $245.00 Sizes 500 µg Source E.coli

TXN protein (His tag) - 80R-1295 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

VAC14 - H00055697-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VAC14 - H00055697-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VAC14 - H00055697-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VAC14 - H00055697-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VAC14 fusion protein - Ag8415 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

VAC14 fusion protein - ag8409 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human VAC14, His-tagged - VAC14-29818TH from Creative Biomart Category Protein Source E. coli Species Human

TXN 1-105 aa - CMB-363 from Reagent Proteins Category Protein Prices $441.00, $805.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Human Protein VAC14 homolog(VAC14) ,partial - CSB-YP600170HU CSB-EP600170HU CSB-BP600170HU CSB-MP600170HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Trx (1-105) - sc-4658 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

VAC14 - TP314195 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

VAC14 Protein - NBP1-89002PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

VAC14-Blocking-Peptide-C-term - BP20783c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VAC14-Blocking-Peptide-N-Term - BP21773a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VAC14 Peptide, Human - M34GP17224H from Creative Peptides Category Peptide Source Synthetic. Species Human

Protein VAC14 homolog (VAC14), partial, Recombinant Protein - MBS1475231 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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