VAC14

Gene Symbol VAC14
Entrez Gene 55697
Alt Symbol ArPIKfyve, TAX1BP2, TRX
Species Human
Gene Type protein-coding
Description Vac14 homolog (S. cerevisiae)
Other Description Tax1 (human T-cell leukemia virus type I) binding protein 1|Tax1 (human T-cell leukemia virus type I) binding protein 2|protein VAC14 homolog|tax1-binding protein 2
Swissprots B3KSM8 Q9BW96 Q6IA12 Q9H6V6 B3KPJ5 Q13174 Q08AM6 Q7L4Y1
Accessions EAW51791 EAW51792 EAW51793 EAW51794 EAW51795 Q08AM6 AK001167 BAA91530 AK025479 BAB15145 AK056433 BAG51707 AK090627 AK093941 BAG52790 AK128439 AK297564 BAG59956 AK307766 AK310466 AL137396 CAB70724 BC000536 AAH00536 BC007214 AAH07214 BC110072 BC110852 BC125108 AAI25109 BC125109 AAI25110 CR457343 CAG33624 U25801 AAB03813 XM_005256038 XP_005256095 XM_005256041 XP_005256098 XM_011523223 XP_011521525 XM_011523224 XP_011521526 XM_011523225 XP_011521527 NM_018052 NP_060522
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}.
Subcellular Location Endosome membrane {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:8611628}.
Top Pathways HTLV-I infection, Viral carcinogenesis

VAC14 (F-12) - sc-365272 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VAC14 (F-12): sc-365272. Western blot analysis of VAC14 expression in HeLa whole cell lysate.

VAC14 (C-10) - sc-271831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VAC14 (C-10): sc-271831. Western blot analysis of VAC14 expression in Hep G2 (A) and K-562 (B) whole cell lysates.

VAC14 (C-14) - sc-109135 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

VAC14 (H-261) - sc-98632 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VAC14 (H-261): sc-98632. Western blot analysis of VAC14 expression in non-transfected: sc-117752 (A) and mouse VAC14 transfected: sc-124533 (B) 293T whole cell lysates.

VAC14 (K-14) - sc-109136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VAC14 (K-14): sc-109136. Western blot analysis of VAC14 expression in Hep G2 (A), K-562 (B) and Jurkat (C) whole cell lysates.

Trx (K-20) - sc-801 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Trx (K-20): sc-801. Western blot analysis of Trx-tagged fusion protein.

Trx (Trx1) - sc-13526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Trx (Trx1): sc-13526. Western blot analysis of Trx-tagged fusion protein.

Anti-VAC14 antibody - ab67369 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-VAC14 antibody (ab67369) at 1/500 dilution + Human liver tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-VAC14 antibody - ab117940 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-VAC14 antibody (ab117940) at 1 µg/ml + Jurkat cell lysate at 10 µg

Anti-VAC14 / TRX Antibody (aa711-760) IHC-plus™ - LS-B12022 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-VAC14 / TRX Antibody (aa769-802) - LS-C344625 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from rat spleen tissue lysate with VAC14 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

VAC14 Antibody - H00055697-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: VAC14 Antibody [H00055697-B01P] - Analysis of VAC14 expression in human liver.

VAC14 Antibody - NBP1-89002 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: VAC14 Antibody [NBP1-89002] - Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

VAC14 Antibody (3B2) - H00055697-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B2

Anti-VAC14 antibody produced in rabbit - HPA027766 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-VAC14: <B>Cat. No. HPA027766</B>: Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

Monoclonal Anti-VAC14 antibody produced in mouse - SAB1401760 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B2
<B>Immunoblotting</B><BR/>Monoclonal Anti-VAC14, antibody produced in mouse, clone 3B2, purified immunoglobulin: <B>Cat. No. SAB1401760</B>: Antibody concentration: 1.0 μg/mL. Specific band of ~33.7 kDa using immunogen protein lysate.

Anti-VAC14 antibody produced in rabbit - SAB4200074 from Sigma-Aldrich

Prices $61.10, $360.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Cytoplasmic and nuclear localization of VAC14 in HeLa cells. Fixed cells were stained with 8 μg/mL Anti-VAC14 (<B>Cat. No. SAB4200074</B>) followed by Goat Anti-Rabbit IgG, Cy3 conjugate (×40 magnification). Nuclear staining with DAPI.

Anti-VAC14 antibody produced in mouse - SAB1400627 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-VAC14, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400627</B>: Antibody concentration: 1.0 μg/mL using HeLa cells.

Anti-VAC14 (C-terminal) antibody produced in rabbit - SAB4200075 from Sigma-Aldrich

Prices $61.10, $360.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Cytoplasmic and nuclear localization of VAC14 in HeLa cells. Fixed cells were stained with 8 μg/mL Anti-VAC14 (C-terminal) (<B>Cat. No. SAB4200075</B>) followed by Goat Anti-Rabbit IgG, Cy3 conjugate (×40 magnification). Nuclear staining with DAPI.

VAC14 antibody - C-terminal region (ARP61721_P050) - ARP61721_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VAC14 Antibody - C-terminal region (ARP74333_P050) - ARP74333_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VAC14-Antibody-C-term - AP20783c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysate from rat spleen tissue lysate, using VAC14 Antibody (C-term)(Cat. #AP20783c). AP20783c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

VAC14 antibody - 70R-21228 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

VAC14 Antibody - abx037257 from Abbexa

Host Rabbit
Clonality Polyclonal

VAC14 antibody - 15771-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human skin using 15771-1-AP(VAC14 antibody) at dilution of 1:100 (under 40x lens)
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