| Gene Symbol |
VAC14
|
| Entrez Gene |
55697
|
| Alt Symbol |
ArPIKfyve, TAX1BP2, TRX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Vac14 homolog (S. cerevisiae)
|
| Other Description |
Tax1 (human T-cell leukemia virus type I) binding protein 1|Tax1 (human T-cell leukemia virus type I) binding protein 2|protein VAC14 homolog|tax1-binding protein 2
|
| Swissprots |
B3KSM8 Q9BW96 Q6IA12 Q9H6V6 B3KPJ5 Q13174 Q08AM6 Q7L4Y1
|
| Accessions |
EAW51791 EAW51792 EAW51793 EAW51794 EAW51795 Q08AM6 AK001167 BAA91530 AK025479 BAB15145 AK056433 BAG51707 AK090627 AK093941 BAG52790 AK128439 AK297564 BAG59956 AK307766 AK310466 AL137396 CAB70724 BC000536 AAH00536 BC007214 AAH07214 BC110072 BC110852 BC125108 AAI25109 BC125109 AAI25110 CR457343 CAG33624 U25801 AAB03813 XM_005256038 XP_005256095 XM_005256041 XP_005256098 XM_011523223 XP_011521525 XM_011523224 XP_011521526 XM_011523225 XP_011521527 NM_018052 NP_060522
|
| Function |
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}.
|
| Subcellular Location |
Endosome membrane {ECO:0000269|PubMed:15542851, ECO:0000269|PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:8611628}.
|
| Top Pathways |
HTLV-I infection, Viral carcinogenesis
|