| Gene Symbol |
FADD
|
| Entrez Gene |
8772
|
| Alt Symbol |
GIG3, MORT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Fas (TNFRSF6)-associated via death domain
|
| Other Description |
FAS-associated death domain protein|Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor induced toxicity|mediator of receptor-induced toxicity
|
| Swissprots |
Q14866 Q13158 Q6IBR4
|
| Accessions |
AAB58469 AAB58483 ABD96828 EAW74760 EAW74761 EAW74762 Q13158 AI886015 AK291005 BAF83694 AK293320 BAG56839 AL575732 AY423721 AAS00484 BC000334 AAH00334 BC025733 BT006927 AAP35573 CR456738 CAG33019 EU176185 ABW03636 U24231 AAA86517 X84709 CAA59197 NM_003824 NP_003815
|
| Function |
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225}.
|
| Tissue Specificity |
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
|
| Top Pathways |
Chagas disease (American trypanosomiasis), TNF signaling pathway, Herpes simplex infection, Tuberculosis, Apoptosis
|