FADD

Gene Symbol FADD
Entrez Gene 8772
Alt Symbol GIG3, MORT1
Species Human
Gene Type protein-coding
Description Fas (TNFRSF6)-associated via death domain
Other Description FAS-associated death domain protein|Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor induced toxicity|mediator of receptor-induced toxicity
Swissprots Q14866 Q13158 Q6IBR4
Accessions AAB58469 AAB58483 ABD96828 EAW74760 EAW74761 EAW74762 Q13158 AI886015 AK291005 BAF83694 AK293320 BAG56839 AL575732 AY423721 AAS00484 BC000334 AAH00334 BC025733 BT006927 AAP35573 CR456738 CAG33019 EU176185 ABW03636 U24231 AAA86517 X84709 CAA59197 NM_003824 NP_003815
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. {ECO:0000269|PubMed:16762833, ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:21109225}.
Tissue Specificity Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Top Pathways Chagas disease (American trypanosomiasis), TNF signaling pathway, Herpes simplex infection, Tuberculosis, Apoptosis

Phospho-FADD (Ser194) Antibody (Human Specific) - 2781 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and HeLa cells, hydroxyurea-treated (4 mM, 20 hours) or nocodazole-treated (1 µg/ml, 20 hours), using Phospho-FADD Ser194 Antibody (Human Specific) (upper) or control FADD Antibody (Human Specific) #2782 (lower).

FADD Antibody (Human Specific) - 2782 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and HeLa cells treated with 4 mM hydroxyurea or 1 µg/ml nocodazole (each for 20 hours), using FADD Antibody (Human Specific).

FADD (G-4) - sc-271748 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FADD (G-4): sc-271748. Western blot analysis of FADD expression in non-transfected 293T: sc-117752 (A), mouse FADD transfected 293T: sc-126821 (B) and A-431 (C) whole cell lysates.

FADD (H-10) - sc-271520 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FADD (H-10): sc-271520. Western blot analysis of FADD expression in THP-1 whole cell lysate.

FADD (H-181) - sc-5559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FADD (H-181): sc-5559. Western blot analysis of human recombinant FADD expression in A-431 cells.

FADD (S-18) - sc-6035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FADD (S-18): sc-6035. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

p-FADD (Ser 191) - sc-33399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-FADD (Ser 191): sc-33399. Western blot analysis of FADD phosphorylation in SW480 whole cell lysate.

p-FADD (Ser 194) - sc-12439 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-FADD (Ser 194): sc-12439. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing nuclear staining of glandular cells.

Anti-FADD (phospho S191) antibody - ab111379 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FADD (phospho S191) antibody (ab111379) at 1/500 dilutionLane 1 : Jurkat cell extracts, treated with PMA (125ng/ml, 30mins)Lane 2 : Jurkat cell extracts, treated with PMA (125ng/ml, 30mins) with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-FADD (phospho S194) antibody - ab55334 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FADD (phospho S194) antibody (ab55334) at 1/500 dilutionLane 1 : Extracts from HeLa cells treated with Paclitaxel (1µM, 60mins).Lane 2 : Extracts from HeLa cells treated with Paclitaxel (1µM, 60mins), and with the immunising phosphpeptide.

Anti-FADD (phospho S194) antibody [EPR1816Y] - ab68475 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1816Y
All lanes : Anti-FADD (phospho S194) antibody [EPR1816Y] (ab68475) at 1/500 dilutionLane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate, treated with calyculin A.Lysates/proteins at 10 µg per lane.SecondaryHRP conjugated Goat anti-Rabbit at 1/2000 dilution

Anti-FADD antibody - ab24533 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab24533 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab24533, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FADD antibody - ab55399 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human lung carcinoma tissue using ab55399 (1/50 dilution) in the presence and absence of immunizing peptide.

Anti-FADD antibody - ab48577 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FADD antibody (ab48577) at 0.5 µg/ml (in 5% skim milk / PBS buffer) + Fetal thymus lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-FADD antibody [1C11] - ab119059 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C11
All lanes : Anti-FADD antibody [1C11] (ab119059) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY FADD cDNALysates/proteins at 5 µg per lane.

Anti-FADD antibody [EP887Y] - ab52935 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP887Y
ab52935 staining FADD in the A549 cell line by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with 4% Paraformaldehyde permeabilized with 0.1% Triton X-100. Samples were incubated with primary antibody (1/100). ab150077(1/500) an Alexa Fluor®488-conjugated Goat anti-rabbit IgG was used as the secondary antibody. Nuclei were counterstained with DAPI.

Anti-FADD antibody [EPR4415] - ab108601 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4415
All lanes : Anti-FADD antibody [EPR4415] (ab108601) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : SKBR-3 cell lysateLysates/proteins at 10 µg per lane.

Anti-FADD antibody [FD19] - ab10519 from Abcam

Prices $372.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone FD19

Anti-FADD antibody - C-terminal - ab196822 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FADD antibody - C-terminal (ab196822) at 1/500 dilutionLane 1 : A549 cell extract with treated with synthesized peptideLane 2 : A549 cell extract

Anti-FADD Antibody IHC-plus™ - LS-B3270 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FADD antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3270 concentration 10 ug/ml.

Anti-FADD Antibody (phospho-Ser191) - LS-C96871 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-mFADD antibody in mouse heart tissue lysate.mFADD(arrow) was detected using the purified antibody.

Anti-FADD Antibody (aa109-208, clone 10C190, Azide-free) - LS-C183613 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 10C190

Anti-FADD Antibody (clone 1F7) - LS-C179765 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F7

Anti-FADD Antibody (Internal) - LS-C209827 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-FADD Antibody (C-Terminus, clone EPR5030) - LS-C138299 from LifeSpan Bioscience

Prices $490.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5030
IHC of paraffin-embedded mouse kidney tissue using anti-FADD (mouse) antibody.
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