Gene Symbol | RNASE3 |
---|---|
Entrez Gene | 6037 |
Alt Symbol | ECP, RNS3 |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease, RNase A family, 3 |
Other Description | RNase 3|cytotoxic ribonuclease|eosinophil cationic protein|ribonuclease 3 |
Swissprots | Q4VBC1 P12724 Q8WZ62 Q9GZN9 Q8WTP7 |
Accessions | AAG31589 AAG31590 AAG31591 AAG31592 AAG31593 AAG31594 AAG31595 AAG31596 AAL35279 AAL35280 AAL35281 CAA34545 CAA39462 EAW66436 P12724 BC096060 AAH96060 BC096061 AAH96061 BC096062 AAH96062 BX280390 M28128 AAA50283 X15161 CAA33251 NM_002935 NP_002926 |
Function | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269|PubMed:19450231, ECO:0000269|PubMed:2501794}. |
Subcellular Location | Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus. |
Top Pathways | Asthma |