RNASE3

Gene Symbol RNASE3
Entrez Gene 6037
Alt Symbol ECP, RNS3
Species Human
Gene Type protein-coding
Description ribonuclease, RNase A family, 3
Other Description RNase 3|cytotoxic ribonuclease|eosinophil cationic protein|ribonuclease 3
Swissprots Q4VBC1 P12724 Q8WZ62 Q9GZN9 Q8WTP7
Accessions AAG31589 AAG31590 AAG31591 AAG31592 AAG31593 AAG31594 AAG31595 AAG31596 AAL35279 AAL35280 AAL35281 CAA34545 CAA39462 EAW66436 P12724 BC096060 AAH96060 BC096061 AAH96061 BC096062 AAH96062 BX280390 M28128 AAA50283 X15161 CAA33251 NM_002935 NP_002926
Function Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269|PubMed:19450231, ECO:0000269|PubMed:2501794}.
Subcellular Location Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Top Pathways Asthma

ECP CRISPR/Cas9 KO Plasmid (h) - sc-404327 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP HDR Plasmid (h) - sc-404327-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP Double Nickase Plasmid (h) - sc-404327-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP Double Nickase Plasmid (h2) - sc-404327-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP CRISPR Activation Plasmid (h) - sc-404327-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP CRISPR Activation Plasmid (h2) - sc-404327-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP Lentiviral Activation Particles (h) - sc-404327-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP Lentiviral Activation Particles (h2) - sc-404327-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP siRNA (h) - sc-105319 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ECP shRNA Plasmid (h) - sc-105319-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ECP shRNA (h) Lentiviral Particles - sc-105319-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNASE3 RNAi - H00006037-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU011441 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18346 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18346 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00271 from Sigma-Aldrich

Category miRNA

RNASE3 siRNA (Human) - CRH4088 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNASE3 - MBS8201340 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ECP CRISPR/Cas9 KO Plasmid (h2) - sc-404327-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ECP HDR Plasmid (h2) - sc-404327-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human RNASE3 (NM_002935.2) - SHH396312 from Creative biogene

Category siRNA
Species Reactivities Human

RNASE3 shRNA Plasmid (Human) - CHH4088 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNASE3 miRNA 3'UTR clone - MiUTR1H-08855 from Creative biogene

Species Reactivities Human
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