Gene Symbol | SERPIND1 |
---|---|
Entrez Gene | 3053 |
Alt Symbol | D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10 |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
Other Description | heparin cofactor 2|leuserpin 2|protease inhibitor leuserpin-2|serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1|serpin D1 |
Swissprots | D3DX34 P05546 B2RAI1 Q6IBZ5 |
Accessions | AAA36185 AAA52641 EAX02941 EAX02942 P05546 AK225292 AK314200 BAG36878 BC035028 AAH35028 BP237845 CR456573 CAG30459 CU013172 CAK54603 CU013460 CAK54902 DQ891203 ABM82129 DQ894386 ABM85312 M12849 AAA52642 X03498 CAA27218 NM_000185 NP_000176 |
Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083}. |
Tissue Specificity | Expressed predominantly in liver. Also present in plasma. |
Top Pathways | Complement and coagulation cascades |