Gene Symbol | SERPIND1 |
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Entrez Gene | 3053 |
Alt Symbol | D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10 |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
Other Description | heparin cofactor 2|leuserpin 2|protease inhibitor leuserpin-2|serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1|serpin D1 |
Swissprots | D3DX34 P05546 B2RAI1 Q6IBZ5 |
Accessions | AAA36185 AAA52641 EAX02941 EAX02942 P05546 AK225292 AK314200 BAG36878 BC035028 AAH35028 BP237845 CR456573 CAG30459 CU013172 CAK54603 CU013460 CAK54902 DQ891203 ABM82129 DQ894386 ABM85312 M12849 AAA52642 X03498 CAA27218 NM_000185 NP_000176 |
Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. {ECO:0000269|PubMed:1939083}. |
Tissue Specificity | Expressed predominantly in liver. Also present in plasma. |
Top Pathways | Complement and coagulation cascades |
HCII (N-18) - sc-25250 from Santa Cruz Biotechnology
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HCII (H-300) - sc-366443 from Santa Cruz Biotechnology
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HCII (74E5) - sc-69784 from Santa Cruz Biotechnology
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Anti-Heparin Cofactor II antibody - ab196758 from Abcam
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Anti-Heparin Cofactor II antibody - ab153929 from Abcam
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Anti-Heparin Cofactor II antibody - ab61371 from Abcam
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Anti-Heparin Cofactor II antibody - ab97846 from Abcam
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Anti-Heparin Cofactor II antibody - ab31661 from Abcam
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Anti-Heparin Cofactor II antibody [74E5] - ab51051 from Abcam
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C24193 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C24192 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C24194 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (aa20-499, Biotin) - LS-C39047 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C129656 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C150904 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C147784 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (Asp68) - LS-C193125 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C193656 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (HRP) - LS-C193823 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C193898 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (aa276-499, Biotin) - LS-C298013 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (aa276-499, FITC) - LS-C305110 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody - LS-C62004 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (aa41-90) - LS-C118757 from LifeSpan Bioscience
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Anti-SERPIND1 / Heparin Cofactor 2 Antibody (aa323-372) - LS-C107501 from LifeSpan Bioscience
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