| Gene Symbol |
GOPC
|
| Entrez Gene |
57120
|
| Alt Symbol |
CAL, FIG, GOPC1, PIST, dJ94G16.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
golgi-associated PDZ and coiled-coil motif containing
|
| Other Description |
CFTR-associated ligand|Golgi associated PDZ and coiled-coil motif containing protein|Golgi-associated PDZ and coiled-coil motif-containing protein|PDZ protein interacting specifically with TC10|PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10|dJ94G16.2 PIST|fused in glioblastoma|golgi-associated PDZ and coiled-coil motif containing protein
|
| Swissprots |
Q9HD26 Q969U8 Q59FS4 A6NM30
|
| Accessions |
EAW48204 EAW48205 Q9HD26 AB209385 BAD92622 AF287894 AAG00572 AF450008 AAL47160 AJ420540 AK025074 AK314486 AY033606 AAK57733 BC009553 AAH09553 BX419592 DA109449 HQ447312 ADQ31799 KF420122 AGU13713 KF420123 AGU13714 NM_001017408 NP_001017408 NM_020399 NP_065132
|
| Function |
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. {ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775}.
|
| Subcellular Location |
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11162552, ECO:0000269|PubMed:11384996, ECO:0000269|PubMed:11707463}.
|
![Western Blot: PIST Overexpression Lysate (Adult Normal) [NBP2-06654] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PIST.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4944_PIST%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06654-img0001.jpg)