GOPC
| Gene Symbol | GOPC |
|---|---|
| Entrez Gene | 57120 |
| Alt Symbol | CAL, FIG, GOPC1, PIST, dJ94G16.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | golgi-associated PDZ and coiled-coil motif containing |
| Other Description | CFTR-associated ligand|Golgi associated PDZ and coiled-coil motif containing protein|Golgi-associated PDZ and coiled-coil motif-containing protein|PDZ protein interacting specifically with TC10|PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10|dJ94G16.2 PIST|fused in glioblastoma|golgi-associated PDZ and coiled-coil motif containing protein |
| Swissprots | Q9HD26 Q969U8 Q59FS4 A6NM30 |
| Accessions | EAW48204 EAW48205 Q9HD26 AB209385 BAD92622 AF287894 AAG00572 AF450008 AAL47160 AJ420540 AK025074 AK314486 AY033606 AAK57733 BC009553 AAH09553 BX419592 DA109449 HQ447312 ADQ31799 KF420122 AGU13713 KF420123 AGU13714 NM_001017408 NP_001017408 NM_020399 NP_065132 |
| Function | Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. {ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775}. |
| Subcellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11162552, ECO:0000269|PubMed:11384996, ECO:0000269|PubMed:11707463}. |
PIST CRISPR/Cas9 KO Plasmid (h) - sc-404939 from Santa Cruz Biotechnology
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PIST HDR Plasmid (h) - sc-404939-HDR from Santa Cruz Biotechnology
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PIST Double Nickase Plasmid (h) - sc-404939-NIC from Santa Cruz Biotechnology
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PIST Double Nickase Plasmid (h2) - sc-404939-NIC-2 from Santa Cruz Biotechnology
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PIST CRISPR Activation Plasmid (h) - sc-404939-ACT from Santa Cruz Biotechnology
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PIST CRISPR Activation Plasmid (h2) - sc-404939-ACT-2 from Santa Cruz Biotechnology
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PIST Lentiviral Activation Particles (h) - sc-404939-LAC from Santa Cruz Biotechnology
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PIST Lentiviral Activation Particles (h2) - sc-404939-LAC-2 from Santa Cruz Biotechnology
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PIST siRNA (h) - sc-76148 from Santa Cruz Biotechnology
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PIST shRNA Plasmid (h) - sc-76148-SH from Santa Cruz Biotechnology
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PIST shRNA (h) Lentiviral Particles - sc-76148-V from Santa Cruz Biotechnology
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PIST RNAi - H00057120-R02 from Novus Biologicals
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MISSION® esiRNA - EHU135141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9485 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9485 from Sigma-Aldrich
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GOPC siRNA (Human) - CRJ1336 from Cohesion Biosciences
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PIST RNAi - H00057120-R01 from Novus Biologicals
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GOPC - MBS8216045 from MyBioSource
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Human GOPC siRNA - orb271837 from Biorbyt
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GOPC shRNA Plasmid (Human) - CHJ1336 from Cohesion Biosciences
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GOPC miRNA 3'UTR clone - MiUTR4H-TG03906 from Creative biogene
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