SLC22A4

Gene Symbol SLC22A4
Entrez Gene 6583
Alt Symbol OCTN1
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation/zwitterion transporter), member 4
Other Description ET transporter|ergothioneine transporter|integral membrane transport protein|organic cation/carnitine transporter 1|solute carrier family 22 (organic cation/ergothioneine transporter), member 4|solute carrier family 22 member 4
Swissprots Q9H015 O14546
Accessions BAJ13468 CAJ56219 EAW62340 Q9H015 AB007448 BAA23356 AK309243 AK310818 BC028313 AAH28313 DQ890816 ABM81742 DQ893972 ABM84898 Y09881 CAA71007 XM_006714675 XP_006714738 XM_011543589 XP_011541891 XR_948289 NM_003059 NP_003050
Function Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15795384}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO:0000269|PubMed:14608356, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:9426230}.
Top Pathways Choline metabolism in cancer

OCTN1 (C-13) - sc-19819 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OCTN1 (C-13): sc-19819. Western blot analysis of OCTN1 expression in non-transfected: sc-117752 (A) and human OCTN1 transfected: sc-114319 (B) 293T whole cell lysates.

OCTN1 (P-12) - sc-19820 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SLC22A4 antibody - ab200641 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SLC22A4 antibody (ab200641)Lane 1 : MCF7 whole cell lysateLane 2 : mouse sp2/0 whole cell lysateLane 3 : rat PC12 whole cell lysate

Anti-SLC22A4 antibody - ab107727 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC22A4 antibody (ab107727) at 1/100 dilution + HeLa cell line lysates at 35 µg

Anti-SLC22A4 / OCTN1 Antibody (C-Terminus) - LS-C16933 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (C-Terminus) - LS-C16934 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550, AP) - LS-C217562 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550, Biotin) - LS-C217564 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550, APC) - LS-C217563 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550, FITC) - LS-C217565 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550, PE) - LS-C217567 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550, Azide-free, HRP) - LS-C217566 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (aa521-550) - LS-C325150 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A4 / OCTN1 Antibody (clone 2D3) - LS-C198221 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D3
Detection limit for recombinant GST tagged SLC22A4 is 0.3 ng/ml as a capture antibody.

Anti-SLC22A4 / OCTN1 Antibody (aa514-542) IHC-plus™ - LS-B10568 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC22A4 / OCTN1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

OCTN1/SLC22A4 Antibody (2D3) - H00006583-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D3
Western Blot: OCTN1/SLC22A4 Antibody (2D3) [H00006583-M01] - SlC22A expression in rat kidney. Image form verified customer review.

OCTN1/SLC22A4 Antibody - H00006583-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Monoclonal Anti-SLC22A4 antibody produced in mouse - SAB1402923 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D3

ANTI-SLC22A4 (C-TERM) antibody produced in rabbit - SAB1304892 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC22A4 (C-term): <B>Cat. No. SAB1304892</B>: SLC22A4 Antibody (C-term) western blot analysis in cell line lysates (35 μg/lane).<BR/><B>Lanes:</B><BR/>1. HeLa<BR/>2. K562(lsne2)

SLC22A4 Antibody - C-terminal region (OAAB03385) - OAAB03385 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SLC22A4-Antibody-C-term - AP5986b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SLC22A4 Antibody (C-term) (Cat. #AP5986b) western blot analysis in Hela(lane 1),K562(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC22A4 antibody detected the SLC22A4 protein (arrow).

OCTN1 Antibody - abx121187 from Abbexa

Host Rabbit
Clonality Polyclonal

SLC22A4 Antibody - abx032678 from Abbexa

Host Rabbit
Clonality Polyclonal

SLC22A4 antibody - H00006583-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
SLC22A4 polyclonal antibody (A01), Lot # 061025JCS1. Western Blot analysis of SLC22A4 expression in Daoy.

SLC22A4 antibody - H00006583-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal
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