| Gene Symbol |
SLC22A4
|
| Entrez Gene |
6583
|
| Alt Symbol |
OCTN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic cation/zwitterion transporter), member 4
|
| Other Description |
ET transporter|ergothioneine transporter|integral membrane transport protein|organic cation/carnitine transporter 1|solute carrier family 22 (organic cation/ergothioneine transporter), member 4|solute carrier family 22 member 4
|
| Swissprots |
Q9H015 O14546
|
| Accessions |
BAJ13468 CAJ56219 EAW62340 Q9H015 AB007448 BAA23356 AK309243 AK310818 BC028313 AAH28313 DQ890816 ABM81742 DQ893972 ABM84898 Y09881 CAA71007 XM_006714675 XP_006714738 XM_011543589 XP_011541891 XR_948289 NM_003059 NP_003050
|
| Function |
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15795384}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO:0000269|PubMed:14608356, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:9426230}.
|
| Top Pathways |
Choline metabolism in cancer
|
![Western Blot: SLC22A4 Overexpression Lysate (Adult Normal) [NBP2-04242] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC22A4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4131_SLC22A4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04242-img0001.jpg)