SLC22A4

Gene Symbol SLC22A4
Entrez Gene 6583
Alt Symbol OCTN1
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation/zwitterion transporter), member 4
Other Description ET transporter|ergothioneine transporter|integral membrane transport protein|organic cation/carnitine transporter 1|solute carrier family 22 (organic cation/ergothioneine transporter), member 4|solute carrier family 22 member 4
Swissprots Q9H015 O14546
Accessions BAJ13468 CAJ56219 EAW62340 Q9H015 AB007448 BAA23356 AK309243 AK310818 BC028313 AAH28313 DQ890816 ABM81742 DQ893972 ABM84898 Y09881 CAA71007 XM_006714675 XP_006714738 XM_011543589 XP_011541891 XR_948289 NM_003059 NP_003050
Function Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15795384}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO:0000269|PubMed:14608356, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:9426230}.
Top Pathways Choline metabolism in cancer

OCTN1 CRISPR/Cas9 KO Plasmid (h) - sc-403258 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 HDR Plasmid (h) - sc-403258-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 Double Nickase Plasmid (h) - sc-403258-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 Double Nickase Plasmid (h2) - sc-403258-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 CRISPR Activation Plasmid (h) - sc-403258-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 CRISPR Activation Plasmid (h2) - sc-403258-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 Lentiviral Activation Particles (h) - sc-403258-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 Lentiviral Activation Particles (h2) - sc-403258-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCTN1 siRNA (h) - sc-42558 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCTN1 shRNA Plasmid (h) - sc-42558-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCTN1 shRNA (h) Lentiviral Particles - sc-42558-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCTN1/SLC22A4 RNAi - H00006583-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU108231 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2134 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2134 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03083 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03083

SLC22A4 siRNA (Human) - CRH4471 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A4 - MBS8239874 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC22A4 (NM_003059.2) - SHH409204 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SLC22A4(NM_003059.2) - SHL001728 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC22A4 siRNA - orb264973 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A4 shRNA Plasmid (Human) - CHH4471 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC22A4 miRNA 3'UTR clone - MiUTR1H-09463 from Creative biogene

Species Reactivities Human
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