SLC22A4

Gene Symbol	SLC22A4
Entrez Gene	6583
Alt Symbol	OCTN1
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic cation/zwitterion transporter), member 4
Other Description	ET transporter|ergothioneine transporter|integral membrane transport protein|organic cation/carnitine transporter 1|solute carrier family 22 (organic cation/ergothioneine transporter), member 4|solute carrier family 22 member 4
Swissprots	Q9H015 O14546
Accessions	BAJ13468 CAJ56219 EAW62340 Q9H015 AB007448 BAA23356 AK309243 AK310818 BC028313 AAH28313 DQ890816 ABM81742 DQ893972 ABM84898 Y09881 CAA71007 XM_006714675 XP_006714738 XM_011543589 XP_011541891 XR_948289 NM_003059 NP_003050
Function	Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15795384}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells. {ECO:0000269|PubMed:14608356, ECO:0000269|PubMed:15107849, ECO:0000269|PubMed:9426230}.
Top Pathways	Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC22A4 protein fragment - ab159539 from Abcam Category Protein Source Wheat germ Species Human

SLC22A4 / OCTN1 Antibody Blocking Peptide - LS-E8069 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human OCTN1/SLC22A4 Protein - H00006583-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SLC22A4-Antibody-C-term-Blocking-peptide - BP5986b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

OCTN1 Blocking Peptide - abx161187 from Abbexa Category Peptide Species Human, Mouse, Rat

SLC22A4 - H00006583-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLC22A4 - H00006583-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SLC22A4 fusion protein - ag3974 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Organic Cation/Ergothioneine Transporter (OCTN1) - RPE444Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

OCTN1 Blocking Peptide - CBP3686 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Organic Cation/Ergothioneine Transporter (OCTN1) - RPE444Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Organic Cation/Ergothioneine Transporter Protein (Recombinant) - abx167103 from Abbexa Category Protein Source Human Species Human

SLC22A4 Peptide, Human - M34GP14391H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Organic Cation/Ergothioneine Transporter (OCTN1) - RPU53647 from Biomatik Category Protein Prices $198.00, $387.00, $619.00, $738.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

SLC22A4 Recombinant Protein (OPCD05896) - OPCD05896 from Aviva Systems Biology Category Protein Source E.coli Species Human

Organic Cation/Ergothioneine Transporter, Recombinant Protein - MBS2030285 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Solute carrier family 22 member 4 (SLC22A4), Recombinant Protein - MBS1027443 from MyBioSource Category Protein Prices $2,180.00, $2,635.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Solute carrier family 22 member 4 (SLC22A4), Recombinant Protein - MBS7098348 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

OCTN1 peptide - orb234561 from Biorbyt Category Peptide

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