IL37

Gene Symbol	IL37
Entrez Gene	27178
Alt Symbol	FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Species	Human
Gene Type	protein-coding
Description	interleukin 37
Other Description	FIL1 zeta|IL-1 zeta|IL-1F7b (IL-1H4, IL-1H, IL-1RP1)|IL-1X protein|IL1F7 (canonical product IL-1F7b)|interleukin 1 family member 7|interleukin 1, zeta|interleukin-1 homolog 4|interleukin-1 superfamily z|interleukin-1-related protein|interleukin-23|interleukin-37
Swissprots	Q8TD04 Q9HBF2 Q8TD05 Q9UHA6 Q9HBF3 Q56AP9 B5BU97 Q9NZH6
Accessions	AAX59036 AAX88889 CAD29873 EAW73608 EAW73609 EAW73610 EAW73611 EAW73612 Q9NZH6 AB451333 BAG70147 AB451478 BAG70292 AF167368 AAG29344 AF200496 AAF69252 AF201832 AAF25212 AF251118 AAG14420 AF251119 AAG14421 AF251120 AAG14422 AY071840 AAL67151 AY071841 AAL67154 BC020637 AAH20637 DQ891388 ABM82314 HQ447646 ADQ32131 XM_011510963 XP_011509265 XM_011510964 XP_011509266 NM_014439 NP_055254 NM_173202 NP_775294 NM_173203 NP_775295 NM_173204 NP_775296 NM_173205 NP_775297
Function	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}.
Subcellular Location	Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Tissue Specificity	In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL37 ELISA Kit (Sandwich ELISA) - LS-F8293 from LifeSpan Bioscience Category ELISA Kit Prices $510.00 Sizes 1 plate Sensitivity 3.3 pg/ml Range 81.92-8000 pg/ml

Human IL37 ELISA Kit (Sandwich ELISA) - LS-F10519 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 10 pg/ml Range 81.92-8000 pg/ml

Human IL1F7 / Interleukin-37 ELISA Kit - RAB0687 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human IL-37/IL-1F7 DuoSet ELISA - DY1975 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Human IL23 ELISA kit - 55R-2184 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Human IL23 ELISA kit - 55R-IB49678 from Fitzgerald Category ELISA Kit Prices $825.00 Sizes 96 wells

Mouse IL23 ELISA kit - 55R-2209 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Mouse IL23 ELISA Kit - 55R-1778 from Fitzgerald Category ELISA Kit Prices $440.00 Sizes 1 kit

Rat IL23 ELISA kit - 55R-2167 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Interleukin 1 Zeta (IL1z), Human, ELISA Kit - SEE842Hu from ARP American Research Products Category ELISA Kit Prices $510.00 Sizes 96 t Sensitivity 6.6pg/mL Range 15.6-1,000pg/mL

Interleukin-37, IL37, Human, ELISA Kit - E10078h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 31.2-2000 pg/mL

Interleukin 1 Zeta (IL1z), Human, CLIA Kit - SCE842Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 6.8pg/mL Range 15.6-1,000pg/mL

Human IL-1F7 ELISA - ELH-IL1F7 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 80 pg/mL Range 80 pg/ml - 20000 pg/mL

IL-37, ELISA Kit - MBS2516030 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human IL-37 is 9.375pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 15.625-1000pg/mL

interleukin 1 family, member 7 (zeta) , ELISA Kit - MBS705712 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human IL-37 is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

Interleukin 1 Zeta, ELISA Kit - MBS057899 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS073785 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS101958 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS053834 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS082015 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS089463 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/ml Range 6.25 pg/ml - 200 pg/ml

Interleukin 1 Zeta, ELISA Kit - MBS058497 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS098695 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Zeta, ELISA Kit - MBS083711 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 23, ELISA Kit - MBS030471 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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