IL37
| Gene Symbol | IL37 |
|---|---|
| Entrez Gene | 27178 |
| Alt Symbol | FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 37 |
| Other Description | FIL1 zeta|IL-1 zeta|IL-1F7b (IL-1H4, IL-1H, IL-1RP1)|IL-1X protein|IL1F7 (canonical product IL-1F7b)|interleukin 1 family member 7|interleukin 1, zeta|interleukin-1 homolog 4|interleukin-1 superfamily z|interleukin-1-related protein|interleukin-23|interleukin-37 |
| Swissprots | Q8TD04 Q9HBF2 Q8TD05 Q9UHA6 Q9HBF3 Q56AP9 B5BU97 Q9NZH6 |
| Accessions | AAX59036 AAX88889 CAD29873 EAW73608 EAW73609 EAW73610 EAW73611 EAW73612 Q9NZH6 AB451333 BAG70147 AB451478 BAG70292 AF167368 AAG29344 AF200496 AAF69252 AF201832 AAF25212 AF251118 AAG14420 AF251119 AAG14421 AF251120 AAG14422 AY071840 AAL67151 AY071841 AAL67154 BC020637 AAH20637 DQ891388 ABM82314 HQ447646 ADQ32131 XM_011510963 XP_011509265 XM_011510964 XP_011509266 NM_014439 NP_055254 NM_173202 NP_775294 NM_173203 NP_775295 NM_173204 NP_775296 NM_173205 NP_775297 |
| Function | Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}. |
| Subcellular Location | Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation. |
| Tissue Specificity | In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}. |
IL-1F7 CRISPR/Cas9 KO Plasmid (h) - sc-405865 from Santa Cruz Biotechnology
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IL-1F7 HDR Plasmid (h) - sc-405865-HDR from Santa Cruz Biotechnology
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IL-1F7 Double Nickase Plasmid (h) - sc-405865-NIC from Santa Cruz Biotechnology
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IL-1F7 Double Nickase Plasmid (h2) - sc-405865-NIC-2 from Santa Cruz Biotechnology
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IL-1F7 CRISPR Activation Plasmid (h) - sc-405865-ACT from Santa Cruz Biotechnology
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IL-1F7 CRISPR Activation Plasmid (h2) - sc-405865-ACT-2 from Santa Cruz Biotechnology
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IL-1F7 Lentiviral Activation Particles (h) - sc-405865-LAC from Santa Cruz Biotechnology
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IL-1F7 Lentiviral Activation Particles (h2) - sc-405865-LAC-2 from Santa Cruz Biotechnology
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IL-1F7 siRNA (h) - sc-94860 from Santa Cruz Biotechnology
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IL-1F7 shRNA Plasmid (h) - sc-94860-SH from Santa Cruz Biotechnology
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IL-1F7 shRNA (h) Lentiviral Particles - sc-94860-V from Santa Cruz Biotechnology
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IL-37/IL-1F7 RNAi - H00027178-R02 from Novus Biologicals
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IL-37/IL-1F7 RNAi - H00027178-R04 from Novus Biologicals
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IL-37/IL-1F7 RNAi - H00027178-R05 from Novus Biologicals
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MISSION® esiRNA - EHU140841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10593 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10593 from Sigma-Aldrich
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IL37 siRNA (Human) - CRH9010 from Cohesion Biosciences
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IL-37/IL-1F7 RNAi - H00027178-R03 from Novus Biologicals
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IL-37/IL-1F7 RNAi - H00027178-R01 from Novus Biologicals
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IL37 - MBS8229825 from MyBioSource
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shRNA set against Human IL37 (NM_173205.1) - SHH318965 from Creative biogene
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shRNA set against Human IL1F7(NM_014439.3) - SHL172166 from Creative biogene
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shRNA set against Human IL1F7(NM_173205.1) - SHL172234 from Creative biogene
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shRNA set against Human IL1F7(NM_173203.1) - SHL172270 from Creative biogene
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