IL37

Gene Symbol	IL37
Entrez Gene	27178
Alt Symbol	FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Species	Human
Gene Type	protein-coding
Description	interleukin 37
Other Description	FIL1 zeta|IL-1 zeta|IL-1F7b (IL-1H4, IL-1H, IL-1RP1)|IL-1X protein|IL1F7 (canonical product IL-1F7b)|interleukin 1 family member 7|interleukin 1, zeta|interleukin-1 homolog 4|interleukin-1 superfamily z|interleukin-1-related protein|interleukin-23|interleukin-37
Swissprots	Q8TD04 Q9HBF2 Q8TD05 Q9UHA6 Q9HBF3 Q56AP9 B5BU97 Q9NZH6
Accessions	AAX59036 AAX88889 CAD29873 EAW73608 EAW73609 EAW73610 EAW73611 EAW73612 Q9NZH6 AB451333 BAG70147 AB451478 BAG70292 AF167368 AAG29344 AF200496 AAF69252 AF201832 AAF25212 AF251118 AAG14420 AF251119 AAG14421 AF251120 AAG14422 AY071840 AAL67151 AY071841 AAL67154 BC020637 AAH20637 DQ891388 ABM82314 HQ447646 ADQ32131 XM_011510963 XP_011509265 XM_011510964 XP_011509266 NM_014439 NP_055254 NM_173202 NP_775294 NM_173203 NP_775295 NM_173204 NP_775296 NM_173205 NP_775297
Function	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}.
Subcellular Location	Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Tissue Specificity	In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL37 full length protein - ab153288 from Abcam Category Protein Source Wheat germ Species Human

Human IL37 full length protein - ab193751 from Abcam Category Protein Source Mammalian Species Human

Human IL37 protein fragment - ab151873 from Abcam Category Protein Source E. coli Species Human

Recombinant Human IL-37/IL-1F7 Protein - H00027178-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human IL-37/IL-1F7, CF - 1975-IL-025 from R&D Systems Category Protein Source E. coli-derived, Lys27-Asp192, with an N-terminal Met

Recombinant Human IL-37b/IL-1F7b - 7585-IL-025 from R&D Systems Category Protein Source E. coli-derived, Val46-Asp218

Recombinant Human IL-37b/IL-1F7b, CF - 7585-IL-025/CF from R&D Systems Category Protein Source E. coli-derived, Val46-Asp218

Human IL1F7 protein - orb49479 from Biorbyt Category Protein Prices $366.00, $706.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human IL1F7 protein Native - orb139148 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

Human IL37 protein - orb168595 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human Interleukin 1 Zeta Protein - abx067422 from Abbexa Category Protein Source E.coli Species Human

IL-37 Blocking Peptide - abx063819 from Abbexa Category Peptide Species Human, Mouse, Rat

IL1F7 / FIL1Z - H00027178-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IL1F7 / FIL1Z - H00027178-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Interleukin-37, Human Recombinant - 228-11884-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Interleukin-23, Human Recombinant - 228-11919-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source HEK. Species Human

Recombinant Human Interleukin-23 - 228-11919-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source HEK 293 cells. Species Human

Recombinant Human Interleukin-23 - 228-11919-3 from RayBiotech Category Protein Prices $1,448.00 Sizes 3 µg Source HEK 293 cells. Species Human

Interleukin 1 Zeta (IL1z), Human - 20-9014 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

Interleukin-37, IL-37, Human, Recombinant - 19-C073 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

IL-37 Peptide - 7499P from ProSci Category Peptide Species Human

IL 37 Recombinant Protein - 96-450 from ProSci Category Protein Source E. coli Species Human

IL 37 Recombinant Protein - 96-462 from ProSci Category Protein Prices $375.00 Sizes 50 µg Source E. coli Species Human

IL1F7 fusion protein - Ag16311 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

IL1F7 fusion protein - Ag21988 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, pGEX-6P-1 Species Human

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