IL37

Gene Symbol IL37
Entrez Gene 27178
Alt Symbol FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Species Human
Gene Type protein-coding
Description interleukin 37
Other Description FIL1 zeta|IL-1 zeta|IL-1F7b (IL-1H4, IL-1H, IL-1RP1)|IL-1X protein|IL1F7 (canonical product IL-1F7b)|interleukin 1 family member 7|interleukin 1, zeta|interleukin-1 homolog 4|interleukin-1 superfamily z|interleukin-1-related protein|interleukin-23|interleukin-37
Swissprots Q8TD04 Q9HBF2 Q8TD05 Q9UHA6 Q9HBF3 Q56AP9 B5BU97 Q9NZH6
Accessions AAX59036 AAX88889 CAD29873 EAW73608 EAW73609 EAW73610 EAW73611 EAW73612 Q9NZH6 AB451333 BAG70147 AB451478 BAG70292 AF167368 AAG29344 AF200496 AAF69252 AF201832 AAF25212 AF251118 AAG14420 AF251119 AAG14421 AF251120 AAG14422 AY071840 AAL67151 AY071841 AAL67154 BC020637 AAH20637 DQ891388 ABM82314 HQ447646 ADQ32131 XM_011510963 XP_011509265 XM_011510964 XP_011509266 NM_014439 NP_055254 NM_173202 NP_775294 NM_173203 NP_775295 NM_173204 NP_775296 NM_173205 NP_775297
Function Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}.
Subcellular Location Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Tissue Specificity In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}.

Human-IL1F7-cDNA-Clone - DC04927 from Abgent, a WuXi AppTec company

Prices $294.30
Sizes 10 µg
Species Human
Accession BC020637

Human IL1F7 ORF Clone(NM_014439.3) - CDCL167100 from Creative Biomart

Species Human
Accession NM_014439.3

Human IL1F7 ORF clone(NM_173205.1) - CDCL184815 from Creative Biomart

Species Human
Accession NM_173205.1

Human IL37 cDNA clone(NM_173203.1) - CDFG010654 from Creative Biomart

Species Human
Accession NM_173203.1

Human IL37 cDNA clone(NM_173202.1) - CDFG010655 from Creative Biomart

Species Human
Accession NM_173202.1

Human IL37 cDNA clone(NM_173204.1) - CDFG010656 from Creative Biomart

Species Human
Accession NM_173204.1

Human IL37 cDNA clone(NM_173205.1) - CDFG010657 from Creative Biomart

Species Human
Accession NM_173205.1

Human IL37 cDNA clone(NM_014439.3) - CDFH009201 from Creative Biomart

Species Human
Accession NM_014439.3

Human IL37 ORF clone(NM_014439.3) - CDCH387047 from Creative Biomart

Species Human
Accession NM_014439.3

Human IL37 ORF Clone(NM_014439.3) - CDCR297573 from Creative Biomart

Species Human
Accession NM_014439.3

Human IL37 ORF Clone(NM_014439.3) - CDCR297574 from Creative Biomart

Species Human
Accession NM_014439.3

Human IL37 ORF Clone(NM_014439.3) - CDCR297575 from Creative Biomart

Species Human
Accession NM_014439.3

Human IL37 ORF Clone(NM_173202.1) - CDCR321771 from Creative Biomart

Species Human
Accession NM_173202.1

Human IL37 ORF Clone(NM_173202.1) - CDCR321772 from Creative Biomart

Species Human
Accession NM_173202.1

Human IL37 ORF Clone(NM_173203.1) - CDCR321773 from Creative Biomart

Species Human
Accession NM_173203.1

Human IL37 ORF Clone(NM_173203.1) - CDCR321774 from Creative Biomart

Species Human
Accession NM_173203.1

Human IL37 ORF Clone(NM_173204.1) - CDCR321775 from Creative Biomart

Species Human
Accession NM_173204.1

Human IL37 ORF Clone(NM_173204.1) - CDCR321776 from Creative Biomart

Species Human
Accession NM_173204.1

Human IL37 ORF Clone(NM_173205.1) - CDCR321777 from Creative Biomart

Species Human
Accession NM_173205.1

Human IL37 ORF Clone(NM_173205.1) - CDCR321778 from Creative Biomart

Species Human
Accession NM_173205.1

Human IL1F7 ORF clone(NM_173205.1) - CDCL184815 from Creative biogene

Species Human

Human IL37 ORF Clone(NM_014439.3) - CDCR297573 from Creative biogene

Species Human

Mouse IL37 ORF clone (NM_173204.1) - CDCL120627 from Creative biogene

Species Human

Mouse IL37 ORF clone (NM_173202.1) - CDCL120629 from Creative biogene

Species Human

Human IL37 ORF clone (NM_173203.1) - CDCL120631 from Creative biogene

Species Human
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