IL37

Gene Symbol IL37
Entrez Gene 27178
Alt Symbol FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1
Species Human
Gene Type protein-coding
Description interleukin 37
Other Description FIL1 zeta|IL-1 zeta|IL-1F7b (IL-1H4, IL-1H, IL-1RP1)|IL-1X protein|IL1F7 (canonical product IL-1F7b)|interleukin 1 family member 7|interleukin 1, zeta|interleukin-1 homolog 4|interleukin-1 superfamily z|interleukin-1-related protein|interleukin-23|interleukin-37
Swissprots Q8TD04 Q9HBF2 Q8TD05 Q9UHA6 Q9HBF3 Q56AP9 B5BU97 Q9NZH6
Accessions AAX59036 AAX88889 CAD29873 EAW73608 EAW73609 EAW73610 EAW73611 EAW73612 Q9NZH6 AB451333 BAG70147 AB451478 BAG70292 AF167368 AAG29344 AF200496 AAF69252 AF201832 AAF25212 AF251118 AAG14420 AF251119 AAG14421 AF251120 AAG14422 AY071840 AAL67151 AY071841 AAL67154 BC020637 AAH20637 DQ891388 ABM82314 HQ447646 ADQ32131 XM_011510963 XP_011509265 XM_011510964 XP_011509266 NM_014439 NP_055254 NM_173202 NP_775294 NM_173203 NP_775295 NM_173204 NP_775296 NM_173205 NP_775297
Function Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}.
Subcellular Location Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Tissue Specificity In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:20935647}.

IL-1F7 (D-12) - sc-168152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-1F7 (S-12) - sc-168153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL37 antibody - ab57187 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
IL1F7 antibody (ab57187) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-IL37 antibody - ab116282 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL37 antibody (ab116282) at 1 µg/mlLane 1 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lane 2 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 3 : Lung (Human) Tissue LysateLane 4 : Lymph node (Human) Tissue Lysate - adult normal tissue (ab29871)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL37 antibody - ab201307 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL37 antibody (ab201307)Lane 1 : DLD whole cell lysateLane 2 : RAW 264.7 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-IL37 antibody - ab101376 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-IL37 antibody (ab101376) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-IL37 antibody - C-terminal - ab153889 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL37 antibody - C-terminal (ab153889) at 1/1000 dilution + A549 whole cell lysate at 30 µg

Anti-IL37 Antibody (N-Terminus) IHC-plus™ - LS-B10134 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IL37 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10134 concentration 10 ug/ml.

Anti-IL37 Antibody - LS-C345047 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of IL-37 in human rheumatoid arthritis tissue. . Method: Immunohistochemical analysis of a paraffin-embedded rheumatoid arthritis tissue, showing endothelial cells and plasma cells (mature B cells) stained by anti-IL-37 at dilution 1:50 (under X200 lens, Brown color).

Anti-IL37 Antibody (aa100-150) - LS-C148812 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL37 Antibody (aa1-219, Biotin) - LS-C244756 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-IL37 Antibody (aa27-192, FITC) - LS-C305105 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL37 Antibody (aa1-219, Azide-free) - LS-C327646 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IL37 Antibody - LS-C341069 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL37 Antibody (aa46-218) - LS-C314983 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL37.

Anti-IL37 Antibody (aa27-192) - LS-C294811 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL37.

Anti-IL37 Antibody (aa27-192) - LS-C314309 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant IL37.

Anti-IL37 Antibody (clone 6A6) - LS-C133726 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A6
Immunoperoxidase of monoclonal antibody to IL1F7 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

Anti-IL37 Antibody (aa27-192, Biotin) - LS-C298034 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

IL-37/IL-1F7 Antibody - NBP2-27200 from Novus Biologicals

Prices $259.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IL1F7 Antibody [NBP2-27200] - Lysate from human A431 cells in the 1) absence and 2) presence of immunizing peptide, and 3) ThP-1 probed with IL-37 antibody at 3 ug/ml.

IL-37/IL-1F7 Antibody - NBP2-14992 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IL-37/IL-1F7 Antibody [NBP2-14992] - Sample (30 ug of whole cell lysate) A: A431 12% SDS PAGE; antibody diluted at 1:1000.

IL-37/IL-1F7 Antibody - NBP2-14991 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IL1F7 Antibody [NBP2-14991] - Sample (30 ug of whole cell lysate) A: A549 12% SDS PAGE; antibody diluted at 1:1000.

IL-37/IL-1F7 Antibody (261506) [Unconjugated] - MAB1975 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 261506

IL-37/IL-1F7 Antibody [Unconjugated] - AF1975 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human peripheral blood mononuclear cells (PBMCs) untreated (-) or treated (+) with 2 μg/mL LPS for 24 hours and THP‑1 human acute monocytic leukemia cell line untreated (-) or treated (+) with 10 μg/mL LPS for 3 hours and 200 nM PMA for 24 hours. PVDF membrane was probed with 2 µg/mL of Goat Anti-Human IL-37/IL-1F7 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1975) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for IL-37/IL-1F7 at approximately 17 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

IL-37/IL-1F7 Antibody (6A6) - H00027178-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A6
Immunohistochemistry-Paraffin: IL-37/IL-1F7 Antibody (6A6) [H00027178-M06] - Analysis of monoclonal antibody to IL1F7 on formalin-fixed paraffin-embedded human small Intestine. Antibody concentration 3 ug/ml
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