| Gene Symbol |
BLOC1S6
|
| Entrez Gene |
26258
|
| Alt Symbol |
BLOS6, HPS9, PA, PALLID, PLDN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
|
| Other Description |
BLOC-1 subunit 6|biogenesis of lysosomal organelles complex-1, subunit 5, pallidin|biogenesis of lysosome-related organelles complex 1 subunit 6|pallid protein homolog|syntaxin 13 binding protein 1|syntaxin 13-interacting protein pallid
|
| Swissprots |
Q9UL45
|
| Accessions |
EAW77330 Q9UL45 AF080470 AAF08343 AF131859 AK057545 AK128626 BAG54702 AK315581 BAG37954 BC004819 AAH04819 BC026289 JF432566 ADZ15783 NM_012388 NP_036520
|
| Function |
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:21998198}.
|
| Subcellular Location |
Cytoplasm. Endomembrane system; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}.
|