Gene Symbol | BLOC1S6 |
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Entrez Gene | 26258 |
Alt Symbol | BLOS6, HPS9, PA, PALLID, PLDN |
Species | Human |
Gene Type | protein-coding |
Description | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin |
Other Description | BLOC-1 subunit 6|biogenesis of lysosomal organelles complex-1, subunit 5, pallidin|biogenesis of lysosome-related organelles complex 1 subunit 6|pallid protein homolog|syntaxin 13 binding protein 1|syntaxin 13-interacting protein pallid |
Swissprots | Q9UL45 |
Accessions | EAW77330 Q9UL45 AF080470 AAF08343 AF131859 AK057545 AK128626 BAG54702 AK315581 BAG37954 BC004819 AAH04819 BC026289 JF432566 ADZ15783 NM_012388 NP_036520 |
Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:21998198}. |
Subcellular Location | Cytoplasm. Endomembrane system; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}. |
Human Pallidin full length protein - ab124579 from Abcam
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Human Pallidin peptide - ab23186 from Abcam
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Pallidin protein (His-DHFR tag) - ab127509 from Abcam
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PLDN / Pallidin Antibody Blocking Peptide - LS-E25541 from LifeSpan Bioscience
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PLDN / Pallidin Antibody Blocking Peptide - LS-E19793 from LifeSpan Bioscience
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PLDN / Pallidin Antibody Blocking Peptide - LS-E19794 from LifeSpan Bioscience
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Pallidin Recombinant Protein - H00026258-P01 from Novus Biologicals
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Pallidin Partial Recombinant Protein - H00026258-Q01 from Novus Biologicals
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Recombinant Human Pallidin Protein - NBP1-99052 from Novus Biologicals
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Human PLDN protein - orb169038 from Biorbyt
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PLDN Blocking Peptide - 33R-2437 from Fitzgerald
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PLDN Blocking Peptide - 33R-6524 from Fitzgerald
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PLDN protein (His tag) - 80R-2215 from Fitzgerald
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Pallidin Peptide - AC21-0370-P from Abcore
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Pallidin (PLDN) (1-172, His-tag) - AR50297PU-N from Acris Antibodies
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Pallidin (PLDN) (1-172, His-tag) - AR50297PU-S from Acris Antibodies
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Pallidin (PLDN) - H00026258-P01-02 from Acris Antibodies
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Pallidin (PLDN) - H00026258-Q01-10 from Acris Antibodies
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Pallidin (PLDN) - H00026258-Q01-25 from Acris Antibodies
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PLDN, 1-172aa, Human, His tag, E.coli - 01-P1472 from ARP American Research Products
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Pallidin Peptide - 46-128P from ProSci
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PLDN fusion protein - Ag18095 from Proteintech Group
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PLDN fusion protein - Ag1337 from Proteintech Group
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PLDN, 1-172aa, Recombinant Protein - GWB-P0566G from Genway Biotech
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Recombinant Human PLDN, His-tagged - PLDN-1772H from Creative Biomart
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