| Gene Symbol | BLOC1S6 |
|---|---|
| Entrez Gene | 26258 |
| Alt Symbol | BLOS6, HPS9, PA, PALLID, PLDN |
| Species | Human |
| Gene Type | protein-coding |
| Description | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin |
| Other Description | BLOC-1 subunit 6|biogenesis of lysosomal organelles complex-1, subunit 5, pallidin|biogenesis of lysosome-related organelles complex 1 subunit 6|pallid protein homolog|syntaxin 13 binding protein 1|syntaxin 13-interacting protein pallid |
| Swissprots | Q9UL45 |
| Accessions | EAW77330 Q9UL45 AF080470 AAF08343 AF131859 AK057545 AK128626 BAG54702 AK315581 BAG37954 BC004819 AAH04819 BC026289 JF432566 ADZ15783 NM_012388 NP_036520 |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:21998198}. |
| Subcellular Location | Cytoplasm. Endomembrane system; Peripheral membrane protein. Note=It can exist as a soluble protein as well as a peripheral membrane protein. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12019270, ECO:0000269|PubMed:12191018}. |