SKP1

Gene Symbol	SKP1
Entrez Gene	6500
Alt Symbol	EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A
Species	Human
Gene Type	protein-coding
Description	S-phase kinase-associated protein 1
Other Description	OCP-2|RNA polymerase II elongation factor-like protein OCP2|SIII|cyclin A/CDK2-associated p19|cyclin A/CDK2-associated protein p19|cyclin-A/CDK2-associated protein p19|organ of Corti protein 2|organ of Corti protein II|p19skp1|transcription elongation factor B polypeptide 1-like
Swissprots	D3DQ98 P63208 D3DQ97
Accessions	AAB50032 AAB50264 AAB50265 EAW62270 EAW62271 EAW62272 EAW62273 EAW62274 EAW62275 EAW62276 P63208 AI025746 AI028694 AK057110 BC009839 AAH09839 BC020798 AAH20798 BC025673 AAH25673 BC065730 AAH65730 BI552966 BI670085 BQ632052 DQ891512 ABM82438 DQ894703 ABM85629 EU831628 ACE87228 EU831713 ACE86547 U33760 AAC50241 U37558 AAA79202 Z47087 CAA87392 NM_006930 NP_008861 NM_170679 NP_733779
Function	Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(F
Top Pathways	Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SKP1-Over-expression-Lysate - LY11004a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SKP1A 293T Cell Transient Overexpression Lysate(Denatured) - H00006500-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SKP1 overexpression lysate - LY416315 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SKP1 overexpression lysate - LY429322 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SKP1 293 Cell Lysate - 404064 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Skp1 Overexpression Lysate (Native) - NBL1-15994 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Skp1 Overexpression Lysate (Native) - NBP2-07556 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Skp1 p19 (h): 293T Lysate - sc-114049 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SKP1 Over-expression Lysate Product - GWB-BA95DC from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Skp1 Overexpression Lysate (Native) - NBP2-09837 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Skp1 Overexpression Lysate (Denatured) - H00006500-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Skp1 Overexpression Lysate (Denatured) - H00006500-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SKP1 Knockdown Stable Cell Line - CSC-DC014293 from Creative biogene Category Cell Line Species Human

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