| Gene Symbol | SKP1 |
|---|---|
| Entrez Gene | 6500 |
| Alt Symbol | EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A |
| Species | Human |
| Gene Type | protein-coding |
| Description | S-phase kinase-associated protein 1 |
| Other Description | OCP-2|RNA polymerase II elongation factor-like protein OCP2|SIII|cyclin A/CDK2-associated p19|cyclin A/CDK2-associated protein p19|cyclin-A/CDK2-associated protein p19|organ of Corti protein 2|organ of Corti protein II|p19skp1|transcription elongation factor B polypeptide 1-like |
| Swissprots | D3DQ98 P63208 D3DQ97 |
| Accessions | AAB50032 AAB50264 AAB50265 EAW62270 EAW62271 EAW62272 EAW62273 EAW62274 EAW62275 EAW62276 P63208 AI025746 AI028694 AK057110 BC009839 AAH09839 BC020798 AAH20798 BC025673 AAH25673 BC065730 AAH65730 BI552966 BI670085 BQ632052 DQ891512 ABM82438 DQ894703 ABM85629 EU831628 ACE87228 EU831713 ACE86547 U33760 AAC50241 U37558 AAA79202 Z47087 CAA87392 NM_006930 NP_008861 NM_170679 NP_733779 |
| Function | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(F |
| Top Pathways | Wnt signaling pathway, Cell cycle, Ubiquitin mediated proteolysis, TGF-beta signaling pathway, Circadian rhythm |